DCBA-d10
DCBA-d10 is the d10-labeled DCBA (HY-136612). DCBA is the major urinary oxidative metabolite of the insect repellent DEET (HY-B0978). DCBA targets EGFR. DCBA exposure is significantly positively correlated with the risk of liver fibrosis. DCBA can be used in liver fibrosis research.
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- Formule: C12H5D10NO3
- Masse moléculaire:231.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
Drug Metabolite[1]
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 72236-23-8
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Masse moléculaire 231.31
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Formule C12H5D10NO3
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SMILES
OC(C1=CC(C(N(C([2H])(C([2H])([2H])[2H])[2H])C([2H])(C([2H])([2H])[2H])[2H])=O)=CC=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lewis RC, et al. Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico. Environmental health : a global access science source. 2014 Nov 19;13:97. [Content Brief]
[2]. Kuklenyik P, et al. On-line solid phase extraction-high performance liquid chromatography-isotope dilution-tandem mass spectrometry approach to quantify N,N-diethyl-m-toluamide and oxidative metabolites in urine. Anal Chim Acta. 2013 Jul 17;787:267-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DCBA-d10 Related Classifications
HY-W706930 Related Classifications
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Keywords
- DCBA-d10
- Isotope-Labeled Compounds
- Drug Metabolite
- EGFR
- MAPK signaling
- PI3K-Akt
- aldehyde intermediate
- benzyl methyl group
- exposure biomarker
- human urine
- inflammatory
- insect repellent
- liver fibrosis
- on-line SPE-HPLC-APCI-MS/MS
- oxidation
- oxidative stress pathways
- pregnant women
- pro-fibrogenic effects
- receptor tyrosine kinase
- ring-carboxylic acid
- urinary oxidative metabolite
- Inhibitor
- inhibitor
- inhibit