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Cat. No.: HY-187935

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E-0702

E-0702 is a cephalosporin antibacterial compound containing a catechol moiety. E-0702 chelates ferric ions, enters the intracellular compartment of Gram-negative bacteria via the TonB-dependent iron uptake system, and exerts bactericidal effects by inhibiting penicillin-binding proteins (PBPs). E-0702 exhibits iron-regulated bactericidal activity against Gram-negative bacteria and some Gram-positive bacteria, and possesses broad-spectrum anti-Pseudomonas activity. E-0702 can be hydrolyzed by common β-lactamases. E-0702 can be used in research related to bacterial infections.

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CAS No.: 77768-46-8
Formule: C₂₉H₂₃N₇O₁₂S₂
Masse moléculaire:725.66

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E-0702 Chemical Structure

CAS No.: 77768-46-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

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In Vitro

Bacterial Infection

E-0702 is a cephalosporin with activity against Pseudomonas aeruginosa; it acts as an iron chelator and enters Escherichia coli via the tonB-dependent iron transport system, exerting rapid bactericidal action when iron is scarce and the iron transport system is induced, and its resistance mutations are caused by tonB mutations^[1]^[3].
E‑0702 is a novel cephalosporin that is hydrolyzed by plasmid-mediated β‑lactamases, shows weak inhibition against plasmid and chromosomal β‑lactamases, and exhibits an inoculum effect^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 77768-46-8
Masse moléculaire 725.66
Formule C₂₉H₂₃N₇O₁₂S₂
SMILES

OC(C1=C(CSC2=NN=NN2CC(O)=O)CS[C@@]([C@@H]3NC([C@@H](C4=CC=C(C=C4)O)NC(C(C(C5=C6)=O)=COC5=CC(O)=C6O)=O)=O)([H])N1C3=O)=O
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Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Instruction de manipulation (2659 KB)

Références

[1]. Lin YM, et al. Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum Gram-negative antibiotics. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2019 Jun;32(3):425-451.

[2]. Neu HC. In vitro antibacterial activity and beta-lactamase stability of E-0702, a new cephalosporin. Antimicrob Agents Chemother. 1983 Sep;24(3):313-20.

[3]. Watanabe NA, et al. E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system. Antimicrobial agents and chemotherapy. 1987 Apr;31(4):497-504.

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E-0702

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