FR 64822
FR 64822 is a dopamine D2 receptor agonist that can induce antinociceptive activity in rats and mice by indirectly stimulating dopamine D2 receptors. FR 64822 can promote penile erection in juvenile rats and improve amnesia in rats induced by scopolamine during passive avoidance tasks.
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- CAS No.: 102671-35-2
- Formule: C11H14N4O
- Masse moléculaire:218.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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D2 Receptor |
Chemical Information
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CAS No. 102671-35-2
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Masse moléculaire 218.26
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Formule C11H14N4O
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SMILES
O=C(NN1CC=CCC1)NC2=CC=NC=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Protocol for Shuttle Box Test (TDPA)
The Shuttle Box Test for TDPA, or temporally dissociated passive avoidance, measures hippocampus-dependent associative learning by testing whether a rodent avoids entering a dark compartment that was previously paired with foot shock after a temporal delay between dark-compartment entry and shock delivery. The main behavioral readout is crossover or step-through latency from the light chamber into the dark chamber; increased latency across training or retention trials reflects learned avoidance memory rather than motor performance alone.
Pureté et documentation
Références
[1]. Ohkubo Y, et al. Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound. Eur J Pharmacol. 1991 Nov 5;204(2):121-5. [Content Brief]
[2]. Maeda N, et al. A screening concept based on a hypothesis led to the development of a putative cognitive enhancer that stimulates penile erection. Jpn J Pharmacol. 1994 Mar;64(3):147-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FR 64822 Related Classifications
HY-105294 Related Classifications
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