FY-21
FY-21 is a selective inhibitor of LSD1 (IC50=340 nM), with anti-proliferation and anti-colony formation activities. FY-21 enhances p53 expression, down-regulates HOXA9 and MEIS1 expression. FY-21 also induces leukemia cell differentiation to exhibts antitumor activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 3049681-20-8
- Formule: C17H15F3N2O6
- Masse moléculaire:400.31
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
IC50: 340 nM (LSD1)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
83 μM
Compound: 3k; FY-21
|
Cytotoxicity against human MOLM-13 cells incubated for 7 days by CCK8 assay
Cytotoxicity against human MOLM-13 cells incubated for 7 days by CCK8 assay
|
[PMID: 37257211] |
| MV4-11 | IC50 |
42 μM
Compound: 3k; FY-21
|
Cytotoxicity against human MV4-11 cells incubated for 7 days by CCK8 assay
Cytotoxicity against human MV4-11 cells incubated for 7 days by CCK8 assay
|
[PMID: 37257211] |
Chemical Information
-
CAS No. 3049681-20-8
-
Masse moléculaire 400.31
-
Formule C17H15F3N2O6
-
SMILES
OC1=C(C=C2C(NCCC2=C1)C3=CC=C(C=C3)[N+]([O-])=O)O.FC(C(O)=O)(F)F
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FY-21 Related Classifications
HY-155526 Related Classifications
Powered by Bioz