THRA - thyroid hormone receptor alpha Gene

Also Known as AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; c-erbA; ERB-T-1; TRalpha; THRalpha; TRalpha1; TRalpha2; c-ERBA-1; THRalpha1; THRalpha2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7067

About THRA

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:40,062,193-40,093,867 (from NCBI)

This gene has 10 transcripts (splice variants), 460 orthologues, 18 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 66.6), ovary (RPKM 38.9) and 23 other tissues.

Summary

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

THRA Products (4)

mRNA	Protein	Name
NM_001190918.2	NP_001177847.1	thyroid hormone receptor alpha isoform 3
NM_001190919.2	NP_001177848.1	thyroid hormone receptor alpha isoform 2
NM_003250.6	NP_003241.2	thyroid hormone receptor alpha isoform 2
NM_199334.5	NP_955366.1	thyroid hormone receptor alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8710870	GOA
enables TBP-class protein binding	IDA IDA: Inferred from direct assay	8524305	GOA
enables general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	8524305	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	8710870	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9653119	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9653119	GOA
enables thyroid hormone binding	IDA IDA: Inferred from direct assay	8710870	GOA
enables thyroid hormone binding	IPI IPI: Inferred from physical interaction	2879243	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18052923	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	18052923	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1310350	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8710870	GOA
involved in negative regulation of DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	8524305	GOA
involved in negative regulation of RNA polymerase II transcription preinitiation complex assembly	IDA IDA: Inferred from direct assay	8524305	GOA
involved in positive regulation of thyroid hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	1310350	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1310350	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18052923	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8710870	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	22474364	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19158403	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8710870	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THRA Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
490 a.a.

Protein Preferred Names	Protein Names
thyroid hormone receptor alpha	EAR-7

THRA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	THRA	P10827	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	THRA	P10827	SYAP1	Homo sapiens	Q96A49	Validated Y2H	32296183
Intra	THRA	P10827	SYAP1	Homo sapiens	Q96A49	Y2H Array	32296183
Intra	THRA	P10827	SYAP1	Homo sapiens	Q96A49	Y2H Prey Pooling	32296183
Intra	THRA	P10827	TACC1	Homo sapiens	O75410-7	Y2H Array	32296183
Intra	THRA	P10827	TACC1	Homo sapiens	O75410-7	Y2H Prey Pooling	32296183
Intra	THRA	P10827	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	THRA	P10827	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	THRA	P10827	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	THRA	P10827	L3MBTL3	Homo sapiens	Q96JM7	Y2H Array	25416956
Intra	THRA	P10827	PRKAR1B	Homo sapiens	P31321	Validated Y2H	32296183
Intra	THRA	P10827	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	THRA	P10827	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	THRA	P10827	MED1	Homo sapiens	Q15648	Far-WB	9653119
Intra	THRA	P10827	CEP76	Homo sapiens	Q8TAP6	Y2H	21516116
Intra	THRA	P10827	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	THRA	P10827	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	THRA	P10827	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	THRA	P10827	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	THRA	P10827	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	THRA	P10827	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Cross	THRA	P10827	Ncoa6	Rattus norvegicus	Q9JLI4	Y2H	10866662
Cross	THRA	P10827	Ncoa6	Rattus norvegicus	Q9JLI4	Pull Down	10866662

Cross: Cross-species interaction Intra: Intraspecies interaction

THRA Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P810935	THRA Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P82828	Thyroid Hormone Receptor alpha Antibody (YA2573)	WB	Human

Related Diseases

Diseases	Alias
Hypothyroidism, Congenital, Nongoitrous, 6	CHNG6 Congenital Nongoitrous Hypothyroidism 6 Hypothyroidism, Congenital, Non-Goitrous, 6 Hypothyroidism, Congenital, Nongoitrous, Type 6
Resistance To Thyroid Hormone Due To A Mutation In Thyroid Hormone Receptor Alpha	Rtha Resistance To Thyroid Hormone Alpha Resistance To Thyroid Hormone Due To A Mutation In Tra
Hyperthyroxinemia
Bone Giant Cell Tumor	Giant Cell Tumor Of Bone Osteoclastoma Gct Of Bone Bone Giant Cell Tumour Giant Cell Myeloma Giant Cell Neoplasm Of Bone Giant Cell Tumour Of Bone
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Thyroid Hormone Resistance, Generalized, Autosomal Dominant	Thyroid Hormone Resistance Syndrome Thyroid Hormone Resistance GRTHD Gthr Thyroid Hormone Unresponsiveness Generalized Thyroid Hormone Resistance Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Thyroid Hormones Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones Refetoff Syndrome Thyroid Hormone Responsiveness Defect Familial Euthyroid Hyperthyroxinemia, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Erythroleukemia
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Neonatal Thyrotoxicosis
Thyroid Hormone Resistance, Selective Pituitary	PRTH Selective Pituitary Thyroid Hormone Resistance Selective Pituitary Resistance To Thyroid Hormone Familial Hyperthyroidism Due To Inappropriate Thyrotropin Secretion Hyperthyroidism, Familial, Due To Inappropriate Thyrotropin Secretion Pituitary Resistance To Thyroid Hormone
Allan-Herndon-Dudley Syndrome	AHDS Allan-Herndon Syndrome Monocarboxylate Transporter 8 Deficiency MCT8 DEFICIENCY Mental Retardation, X-Linked, With Hypotonia Triiodothyronine Resistance T3 Resistance Mental Retardation And Muscular Atrophy Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency Intellectual Disability And Muscular Atrophy Monocarboxylate Transporter-8 Deficiency T3 Resisitence Triiodothyronine Resistence X-Linked Intellectual Disability With Hypotonia Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency Monocarboxylate Transporter 8 Deficiency X-Linked Intellectual Disability-Hypotonia Syndrome
Thrombasthenia
Graves Disease 1	Thyrotoxicosis Graves Disease, Susceptibility To, 1 GRD1 Grd Hyperthyroidism, Autoimmune Hyperthyroidism Hyperactive Thyroid Gland Overactive Thyroid Toxic Diffuse Goitre Toxic Primary Thyroid Hyperplasia Stokes Disease Thyrotoxicosis With Goitre Thyrotoxicosis Struma Graves Disease Goitre With Hyperthyroidism Basedow Disease Exophthalmic Goitre Exophthalmic Struma Flajani Disease Graves Disease With Exophthalmos Hyperthyroid Goitre Hyperthyroidism Struma Thyroid Exophthalmos Malignant Exophthalmos Parry Disease Toxic Diffuse Goitre With Exophthalmos Toxic Goitre Toxic Goitre Nos Thyrotoxicosis Due To Uninodular Goitre Toxic Thyroid Nodule Toxic Uninodular Goitre Uninodular Toxic Struma Uninodular Toxic Struma With Hyperthyroidism Thyrotoxicosis Due To Single Thyroid Nodule Toxic Uninodular Goitre With Hyperthyroidism Hyperthyroidism With Thyroid Nodule Thyrotoxicosis With Toxic Uninodular Goitre Uninodular Goitre In Hyperthyroidism Uninodular Goitre In Thyrotoxicosis Toxic Multinodular Goitre Multinodular Goitre With Thyrotoxicosis Thyrotoxicosis Nodular Goitre Nodular Goitre With Thyrotoxicosis Adenomatous Goitre With Hyperthyroidism Multinodular Goitre With Hyperthyroidism Nodular Goitre With Hyperthyroidism Nodular Struma With Hyperthyroidism Plummer Disease Thyrotoxicosis Adenomatous Goitre Thyrotoxicosis Adenomatous Struma Toxic Adenomatous Goitre Toxic Adenomatous Struma Toxic Nodular Goitre Nos Toxic Struma Nodosa Toxic Nodular Struma
Thyroid Gland Disease	Abnormality Of The Thyroid Gland Thyroid Diseases
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Acute Erythroid Leukemia	Acute Erythroleukemia Di Guglielmo'S Syndrome Aml M6 Acute Myeloid Leukemia Fab-M6 Acute Myeloid Leukemia M6 Erythroleukemia Aml-M6 Acute Erythroleukemia M6a Subtype Acute Erythroleukemia M6b Subtype Di Guglielmo Syndrome Acute Myeloid Leukemia, M6 Type Acute Erythroblastic Leukemia Acute Erythroleukemia - M6a Subtype Acute Erythroleukemia - M6b Subtype Acute Erythraemia And Erythroleukaemia Acute Erythroid Leukaemia Without Mention Of Remission Erythraemia Erythraemic Myelosis Erythroleukaemia Acute Erythraemic Myelosis Acute Erythraemia
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS14499	THRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17595	Thra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24055	Thra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	THRA	VGNC	VGNC:35845
Rattus norvegicus	THRA	RGD	RGD:3857
Mus musculus	THRA	MGD	MGI:98742
Macaca mulatta	THRA	VGNC	VGNC:78349
Canis familiaris	THRA	VGNC	VGNC:55828
Felis catus	THRA	VGNC	VGNC:66172
Others	THRA	NCBI