BEX2 - brain expressed X-linked 2 Gene
Also Known as BEX1; DJ79P11.1
Species: Homo sapiens
About BEX2
This gene has 4 transcripts (splice variants), 149 orthologues and 3 paralogues. Broad expression in brain (RPKM 60.5), thyroid (RPKM 40.0) and 14 other tissues.
Summary
This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast Cancer cells, this gene product modulates Apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
BEX2 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001168399.2 | NP_001161871.1 | protein BEX2 isoform 1 |
| NM_001168400.2 | NP_001161872.1 | protein BEX2 isoform 2 |
| NM_001168401.2 | NP_001161873.1 | protein BEX2 isoform 3 |
| NM_032621.4 | NP_116010.1 | protein BEX2 isoform 3 |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in regulation of apoptotic process |
IDA
IDA: Inferred from direct assay
|
19711341 | GOA |
| involved in regulation of cell cycle |
IDA
IDA: Inferred from direct assay
|
19711341 | GOA |
BEX2 Protein Structure
BEX: Brain expressed X-linked like family (14 - 127)
- 0
- 100
- 128 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein BEX2 |
|
BEX2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
BEX2 | Q9BXY8 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP10-8 | Homo sapiens | P60410 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | NECAB2 | Homo sapiens | Q7Z6G3-2 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | NECAB2 | Homo sapiens | Q7Z6G3-2 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP12-2 | Homo sapiens | P59991 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP12-2 | Homo sapiens | P59991 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MAGEA11 | Homo sapiens | P43364-2 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | BORCS6 | Homo sapiens | Q96GS4 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | BORCS6 | Homo sapiens | Q96GS4 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MAGEA4 | Homo sapiens | Q1RN33 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | MAGEA4 | Homo sapiens | Q1RN33 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | MAGEA4 | Homo sapiens | Q1RN33 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | TRIM74 | Homo sapiens | Q86UV6-2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRIM74 | Homo sapiens | Q86UV6-2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT38 | Homo sapiens | O76015 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT38 | Homo sapiens | O76015 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT38 | Homo sapiens | O76015 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP11-1 | Homo sapiens | Q8IUC1 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP11-1 | Homo sapiens | Q8IUC1 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KLHL20 | Homo sapiens | Q9BS75 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KLHL20 | Homo sapiens | Q9BS75 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CCDC57 | Homo sapiens | Q2TAC2-2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CCDC57 | Homo sapiens | Q2TAC2-2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | GPRASP3 | Homo sapiens | Q6PI77 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | GPRASP3 | Homo sapiens | Q6PI77 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRIM69 | Homo sapiens | Q86WT6-2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRIM69 | Homo sapiens | Q86WT6-2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MSS51 | Homo sapiens | Q4VC12 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MSS51 | Homo sapiens | Q4VC12 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | AKAP9 | Homo sapiens | Q6PJH3 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | AKAP9 | Homo sapiens | Q6PJH3 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CDR2 | Homo sapiens | Q01850 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CDR2 | Homo sapiens | Q01850 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CTAG1A | Homo sapiens | P78358 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CTAG1A | Homo sapiens | P78358 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | LCN2 | Homo sapiens | P80188 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | LCN2 | Homo sapiens | P80188 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT39 | Homo sapiens | Q6A163 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT39 | Homo sapiens | Q6A163 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP6-2 | Homo sapiens | Q3LI66 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP6-2 | Homo sapiens | Q3LI66 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | VPS28 | Homo sapiens | Q9UK41-2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | VPS28 | Homo sapiens | Q9UK41-2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | VPS28 | Homo sapiens | Q9UK41-2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | SPRY3 | Homo sapiens | O43610 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | SPRY3 | Homo sapiens | O43610 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | ZNF19 | Homo sapiens | P17023 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | ZNF19 | Homo sapiens | P17023 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP2-4 | Homo sapiens | Q9BYR9 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | FST | Homo sapiens | P19883 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | FST | Homo sapiens | P19883 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP21-2 | Homo sapiens | Q3LI59 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP21-2 | Homo sapiens | Q3LI59 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MKRN3 | Homo sapiens | Q13064 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MKRN3 | Homo sapiens | Q13064 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | MKRN3 | Homo sapiens | Q13064 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | BLZF1 | Homo sapiens | Q9H2G9 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | BLZF1 | Homo sapiens | Q9H2G9 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | BLZF1 | Homo sapiens | Q9H2G9 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | BLZF1 | Homo sapiens | Q9H2G9 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | BLZF1 | Homo sapiens | Q9H2G9 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | MIPOL1 | Homo sapiens | Q8TD10 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | TACC3 | Homo sapiens | Q9Y6A5 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TACC3 | Homo sapiens | Q9Y6A5 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TACC3 | Homo sapiens | Q9Y6A5 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT75 | Homo sapiens | O95678 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT75 | Homo sapiens | O95678 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | PNMA1 | Homo sapiens | Q8ND90 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CCDC88B | Homo sapiens | A6NC98 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CCDC88B | Homo sapiens | A6NC98 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRAF2 | Homo sapiens | Q12933 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRAF2 | Homo sapiens | Q12933 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRAF1 | Homo sapiens | Q13077 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | COG4 | Homo sapiens | Q9H9E3 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | COG4 | Homo sapiens | Q9H9E3 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | COG4 | Homo sapiens | Q9H9E3 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KNSTRN | Homo sapiens | Q9Y448 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KNSTRN | Homo sapiens | Q9Y448 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KNSTRN | Homo sapiens | Q9Y448 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP3-3 | Homo sapiens | Q9BYR6 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | PRDM14 | Homo sapiens | Q9GZV8 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP5-9 | Homo sapiens | P26371 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP5-9 | Homo sapiens | P26371 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRTAP5-9 | Homo sapiens | P26371 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | SPRED1 | Homo sapiens | Q7Z699 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | SPRED1 | Homo sapiens | Q7Z699 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRIM42 | Homo sapiens | Q8IWZ5 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | TRIM42 | Homo sapiens | Q8IWZ5 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | OIP5 | Homo sapiens | O43482 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | OIP5 | Homo sapiens | O43482 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MAGEA2 | Homo sapiens | P43356 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MAGEA2 | Homo sapiens | P43356 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | FSD2 | Homo sapiens | A1L4K1 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | FSD2 | Homo sapiens | A1L4K1 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | FSD2 | Homo sapiens | A1L4K1 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | SYCE1 | Homo sapiens | Q8N0S2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | SYCE1 | Homo sapiens | Q8N0S2 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT6A | Homo sapiens | P02538 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT6A | Homo sapiens | P02538 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | HSF2BP | Homo sapiens | O75031 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRIM27 | Homo sapiens | P14373 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | MRPL38 | Homo sapiens | Q96DV4 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MRPL38 | Homo sapiens | Q96DV4 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MDFI | Homo sapiens | Q99750 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | PLA2G10 | Homo sapiens | O15496 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | PLA2G10 | Homo sapiens | O15496 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | HSPB2 | Homo sapiens | Q16082 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | HSPB2 | Homo sapiens | Q16082 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | CEP70 | Homo sapiens | Q8NHQ1 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | CEP70 | Homo sapiens | Q8NHQ1 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | CEP70 | Homo sapiens | Q8NHQ1 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CEP70 | Homo sapiens | Q8NHQ1 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | CEP70 | Homo sapiens | Q8NHQ1 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | USHBP1 | Homo sapiens | Q8N6Y0 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | USHBP1 | Homo sapiens | Q8N6Y0 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | LDOC1 | Homo sapiens | O95751 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | LDOC1 | Homo sapiens | O95751 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | LZTS2 | Homo sapiens | Q9BRK4 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | LZTS2 | Homo sapiens | Q9BRK4 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | LZTS2 | Homo sapiens | Q9BRK4 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | EXOC8 | Homo sapiens | Q8IYI6 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | EXOC8 | Homo sapiens | Q8IYI6 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRIP6 | Homo sapiens | Q15654 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | TRIP6 | Homo sapiens | Q15654 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT19 | Homo sapiens | P08727 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT19 | Homo sapiens | P08727 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | SERTAD3 | Homo sapiens | Q9UJW9 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | SERTAD3 | Homo sapiens | Q9UJW9 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | SERTAD3 | Homo sapiens | Q9UJW9 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CCDC197 | Homo sapiens | Q8NCU1 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | CCDC197 | Homo sapiens | Q8NCU1 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | ROPN1L | Homo sapiens | Q96C74 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | ROPN1L | Homo sapiens | Q96C74 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT31 | Homo sapiens | Q15323 | 25416956 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | PLEKHG4 | Homo sapiens | Q58EX7 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | PLEKHG4 | Homo sapiens | Q58EX7 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MORN3 | Homo sapiens | Q6PF18 | 32296183 | |
|
Intra
|
BEX2 | Q9BXY8 | MORN3 | Homo sapiens | Q6PF18 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Breast Cancer |
|
|
| Oligodendroglioma |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | BEX2 | RGD | RGD:1564643 |
| Others | BEX2 | NCBI |