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Cat. No.: HY-155024

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HAT-IN-8

HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3036127-14-4
Formule: C₁₄H₁₅F₂N₃O₂S
Masse moléculaire:327.35

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HAT-IN-8 Chemical Structure

CAS No.: 3036127-14-4

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	EC₅₀	46 μM Compound: 38	Antiproliferative activity against human MRC5 cells in presence of 5% Co2 incubated for 69 hrs followed by resazurin addition further incubated for 4 hrs Antiproliferative activity against human MRC5 cells in presence of 5% Co2 incubated for 69 hrs followed by resazurin addition further incubated for 4 hrs	[PMID: 37343180]

Chemical Information

CAS No. 3036127-14-4
Masse moléculaire 327.35
Formule C₁₄H₁₅F₂N₃O₂S
SMILES

CC(C)(O)CC(C1=C(N)N=C(NC2=CC=C(F)C(F)=C2)S1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cleghorn LAT, et al. Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues. J Med Chem. 2023 Jul 13;66(13):8896-8916. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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HAT-IN-8

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

HAT-IN-8 Related Classifications

HY-155024 Related Classifications