HS-1793
Based on 1 Customer Validation
HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines. HS-1793 induces cell apoptosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.26%
- CAS No.: 927885-00-5
- Formule: C16H12O3
- Masse moléculaire:252.26
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
>100 μM
Compound: HS-1793
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Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
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[PMID: 32485531] |
| MCF7 | IC50 |
26.3 μM
Compound: HS-1793
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Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
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[PMID: 32485531] |
| MDA-MB-231 | IC50 |
48.2 μM
Compound: HS-1793
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Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
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[PMID: 32485531] |
HS-1793 (0-100 µM; 24 h) suppresses proliferation of MCF-7, MDA-MB-231 and HCT116 cells[1][2].
HS-1793 (0-50 µM; 4 h) inhibits hypoxia-induced HIF-1α protein in MCF-7 and MDA-MB-231 cells unrelated to cell death, downregulates hypoxia-induced VEGF expression, and suppresses hypoxia-induced mRNA expression of VEGF at the transcriptional level[1].
HS-1793 (0-100 µM; 24 h) induces apoptosis, promotes G2/M cell cycle arrest, and inhibits Akt and ERK phosphorylation in HCT116 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, MDA-MB-231 and MCF-10A
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Showed antiproliferation activity with IC50 values of 26.3±3.2, 48.2±4.2 and >100 μM against MCF-7, MDA-MB-231 and MCF-10A, respectively.
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Cell Line:MCF-7, MDA-MB-231
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Concentration:12.5, 25 and 50 μM
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Incubation Time:4 h
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Result:Downregulated HIF-1α expression in a concentration-dependent manner in both cell lines.
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Cell Line:MCF-7, MDA-MB-231
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Concentration:12.5, 25 and 50 μM
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Incubation Time:4 h
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Result:Downregulated the expression of VEGF mRNA, with the more marked results observed in MDA-MB-231 cells.
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Cell Line:HCT116
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Concentration:12.5, 25, 50 and 100 µM
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Incubation Time:1, 2 and 4 days
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Result:Significantly reduced the cell viability concentration- and time-dependently. Significantly suppressed proliferation of colon cancer cell line HCT116.
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Cell Line:HCT116
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Concentration:12.5, 25, 50 and 100 µM
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Incubation Time:24 h
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Result:Induced cell apoptosis in a dose-dependent manner. Caused chromatin condensation and fragmentation.
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Cell Line:HCT116
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Concentration:12.5, 25, 50 and 100 µM
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Incubation Time:24 h
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Result:Effectively induced the reduction of pro-caspase-8 and pro-caspase-3 at 100 µM. Activated caspase-8 and caspase-3. Caused the PARP cleavage. Slightly downregulated the level of antiapoptotic protein Bcl-2 at 100 µM. Promoted an increase in the release of cytochrome c from the mitochondria into the cytosol. Decreased the expression of G2/M cell cycle regulatory protein cyclin B1, Cdc2 and Cdc25C. Decreased the level of CDK4 and CDK6. Decreased Akt phosphorylation and reduced total Akt at high-concentration. Decreased the phosphorylation of ERK1/2 without affecting the protein level.
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Cell Line:HCT116
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Concentration:12.5, 25 and 50 µM
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Incubation Time:24 h
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Result:Induced the accumulation of cells in the G2/M phase in a concentration-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Five-week-old female BALB/c nude mice injected with MDA-MB-231 cells[1]
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Dosage:5 mg/kg and 10 mg/kg (dissolved in PBS containing 0.1% v/v dimethyl sulfoxide (DMSO))
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Administration:Intraperitoneal injection, twice a week, 4 weeks
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Result:Significantly inhibited MDA-MB-231 xenograft tumor growth in a dose-dependent manner with non-toxicity. Significantly lowered Ki-67 (a proliferation marker) and CD31 expression. Successfully suppressed the expression of HIF-1α and VEGF in tumor tissues.
Chemical Information
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CAS No. 927885-00-5
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Appearance Solid
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Masse moléculaire 252.26
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Formule C16H12O3
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Color Off-white to light yellow
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SMILES
OC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C(O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 125 mg/mL (495.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Kim DH, et al. HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model. Int J Oncol. 2017 Aug;51(2):715-723. [Content Brief]
[2]. Kim DH, et al. Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncol Rep. 2017 Jan;37(1):281-288. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9642 mL | 19.8208 mL | 39.6416 mL | 99.1041 mL |
| 5 mM | 0.7928 mL | 3.9642 mL | 7.9283 mL | 19.8208 mL | |
| 10 mM | 0.3964 mL | 1.9821 mL | 3.9642 mL | 9.9104 mL | |
| 15 mM | 0.2643 mL | 1.3214 mL | 2.6428 mL | 6.6069 mL | |
| 20 mM | 0.1982 mL | 0.9910 mL | 1.9821 mL | 4.9552 mL | |
| 25 mM | 0.1586 mL | 0.7928 mL | 1.5857 mL | 3.9642 mL | |
| 30 mM | 0.1321 mL | 0.6607 mL | 1.3214 mL | 3.3035 mL | |
| 40 mM | 0.0991 mL | 0.4955 mL | 0.9910 mL | 2.4776 mL | |
| 50 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9821 mL | |
| 60 mM | 0.0661 mL | 0.3303 mL | 0.6607 mL | 1.6517 mL | |
| 80 mM | 0.0496 mL | 0.2478 mL | 0.4955 mL | 1.2388 mL | |
| 100 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9910 mL |
HS-1793 Related Classifications
HY-129156 Related Classifications
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