Hydroxocobalamin
Based on 3 publication(s) in Google Scholar
Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B12 deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease.
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- Pureté: 99.32%
- CAS No.: 13422-51-0
- Formule: C62H89CoN13O15P
- Masse moléculaire:1346.36
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
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Publications Citing Use of MedChemExpress (MCE) Hydroxocobalamin
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Activité biologique
Hydroxocobalamin (1 mM, 5 mins) recovers sodium cyanide-induced inotropy decrease in cardiac papillary muscle[1].
Hydroxocobalamin (500 μM, 10 mins) decreases intracellular cyanide in fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Yorkshire swine (Sus scrofa); hemorrhage model, induced by volume-controlled and uncontrolled hemorrhage[2]
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Dosage:150 mg/kg
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Administration:Intravenously injection
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Result:Maintained higher systolic blood pressure.
Heart rate (HR), cardiac output (CO), Spo2 and vascular resistance were comparable with whole blood.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 13422-51-0
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Appearance Solid
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Masse moléculaire 1346.36
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Formule C62H89CoN13O15P
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Color Purple to reddish brown
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SMILES
C[C@@]12[N]([Co+3]34([N]5=C[N@@]([C@@H](O[C@H](CO)[C@H]6OP7([O-])=O)[C@@H]6O)C8=C5C=C(C)C(C)=C8)([OH-])[N-]9C2[C@H](CC(N)=O)[C@@](C)(CCC(NC[C@H](C)O7)=O)C9=C(C)C([C@@H](CCC(N)=O)C%10(C)C)=[N]3C%10=CC%11=[N]4C([C@](CC(N)=O)(C)[C@@H]%11CCC(N)=O)=C%12C)=C%12[C@@H](CCC(N)=O)[C@]1(C)CC(N)=O
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Synonyms
Vitamin B12a
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
2025 Jan 31;16(1):1233. PMID: 39890804 -
Nat Commun
Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates. [Abstract]2021 Nov 22;12(1):6786. PMID: 34811361 -
J Clin Transl Hepatol
Hydrogen Sulfide Promotes Platelet Autophagy via PDGFR-α/PI3K/Akt Signaling in Cirrhotic Thrombocytopenia. [Abstract]2024 Jul 28;12(7):625-633. PMID: 38993511
Solvant et solubilité
DMSO : 25 mg/mL (18.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (294 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Thompson JP, et al. Hydroxocobalamin in cyanide poisoning. Clin Toxicol (Phila). 2012;50(10):875-885. [Content Brief]
[2]. Paredes RM, et al. Comparison of hydroxocobalamin with other resuscitative fluids in volume-controlled and uncontrolled hemorrhage models in swine ( Sus-scrofa ). J Trauma Acute Care Surg. 2023;95(2S Suppl 1):S120-S128. [Content Brief]
[3]. Olivieri G, et al. Improved biochemical and neurodevelopmental profiles with high-dose hydroxocobalamin therapy in cobalamin C defect. J Inherit Metab Dis. 2025;48(1):e12787. [Content Brief]
[4]. Dépret F, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. Published 2019 Dec 23. [Content Brief]
[5]. Bruins Slot, et al. Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology. 1997 Aug;113(2):430-3. [Content Brief]
[6]. Shepherd G, et al. Role of hydroxocobalamin in acute cyanide poisoning. Ann Pharmacother. 2008;42(5):661-669. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7427 mL | 3.7137 mL | 7.4274 mL | 18.5686 mL |
| 5 mM | 0.1485 mL | 0.7427 mL | 1.4855 mL | 3.7137 mL | |
| 10 mM | 0.0743 mL | 0.3714 mL | 0.7427 mL | 1.8569 mL | |
| 15 mM | 0.0495 mL | 0.2476 mL | 0.4952 mL | 1.2379 mL |
Hydroxocobalamin Related Classifications
HY-B2209 Related Classifications
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