Ir-CA
Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces apoptosis and autophagy. Ir-CA initiates mitophagy and cell cycle arrest to kill Cisplatin (HY-17394)-resistant A549R cells. Ir-CA can effectively inhibit metastasis by inhibiting MMP-2/MMP-9.
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- CAS No.: 2870682-93-0
- Formule: C43H35F6IrN5OP
- Masse moléculaire:974.95
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Ir-CA shows cytotoxicity against A549, A549R, HLF, BEAS-2B, MCF-7, 4T1 cells with IC50s of 4.4, 4.5, 6.6, 2.3, 2.6, 5.7 μM respectively[1].
Ir-CA is quickly absorbed by the A549R cells (indicated by the red fluorescence after 1 h of incubation)[1].
Ir-CA (10 μM, 2 h) can accumulate in the mitochondria of living A549 and A549R cells (Co-staining experiments of Ir-CA with Mito-Tracker)[1].
Ir-CA (10 μM, 24 h) damages mitochondrial morphology and the mitochondrial function in A549R cells, and induces ROS production[1].
Ir-CA (10 μM, 24 h) induces cell apoptosis in A549R cells via a nonapoptotic/necrotic pathway, and also increases conversion from LC3-I to LC3-II, suggesting the autophagy[1].
Ir-CA (2.5 μM, 24 h) resensitizes the A549R cells to Cisplatin (HY-17394)[1].
Ir-CA (5 μM, 24 h) inhibitS the metastasis of A549R cells via down-regulation of MMPs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ir-CA (5 mg/kg, i.p., once every other day for 14 d) inhibits tumor growth in A549 tumor-bearing Balb/c nude mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2870682-93-0
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Masse moléculaire 974.95
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Formule C43H35F6IrN5OP
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SMILES
CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=[N]3C=CC=C6)([C-]7=C(C=CC=C7)C8=[N]4C=CC=C8)[N]9=CC=C(CNC(/C=C/C%10=CC=CC=C%10)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ir-CA Related Classifications
HY-162344 Related Classifications
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