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Cat. No.: HY-120299

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KC01

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KC01 is an effective inhibitor of ABHD16A, with IC₅₀s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages .

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Pureté: 99.0%
CAS No.: 1646795-59-6
Formule: C₂₂H₃₉NO₃
Masse moléculaire:365.55

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

KC01 Chemical Structure

CAS No.: 1646795-59-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

90 nM for hABHD16A and 520 nM for mABHD16A^[1]

Voir tous les produits spécifiques à Isoform TNF Receptor :

In Vitro

KC01 (0-20 μM, 30 min) is a potent inhibitor of ABHD16A with an IC₅₀ < 90 nM^[1].
KC01 (1 μM, 4 h) significantly reduces lyso-PSs in colon cancer cells (COL205, K562, and MCF7)^[1].
KC01 (1 μM, 4 h) reduces lyso-PS and LPS-induced cytokine production in mouse macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T
Concentration:

0 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM, 2 μM, 5 μM, 10 μM, 20 μM
Incubation Time:

30 min
Result:

Showed KC01 inhbited ABHD16A in a concentration-dependent manner.

Chemical Information

CAS No. 1646795-59-6
Appearance Solid
Masse moléculaire 365.55
Formule C₂₂H₃₉NO₃
Color White to off-white
SMILES

O=C(N)CCCC/C=C1C(OC\1CCCCCCCCCCCCC)=O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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KC01

Voir tous les produits spécifiques à Isoform TNF Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

KC01 Related Classifications

HY-120299 Related Classifications