Kojic amine
Kojic amine is an orally active γ-aminobutyric acid (GABA) analog. Kojic amine acts as a GABA mimic that inhibits sodium-independent [3H]GABA binding to rat brain cell membranes. Kojic amine reduces flexor spasms in chronic spinal rat and cat models. Kojic amine prevents tonic extensor convulsions in mice. Kojic amine produces a transient, dose-dependent analgesic effect in the mouse hot-plate test. Kojic amine can be used in research related to skeletal muscle spasm, epilepsy and analgesia[1][2]
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
Kojic amine (Compound 3) potently and specifically inhibits the Na+-independent binding of [3H]GABA to rat brain cell membranes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
Kojic amine (i.v., oral administration; cumulative dosing) reduces flexor reflex spasm in chronic spinal cats by 70%, with an intravenous ED70 of 2.2 mg/kg and an oral ED70 of 4 mg/kg[1].
Kojic amine (15-128 mg/kg; i.g.; single dose) prevents 3-mercaptopropionic acid-induced tonic extensor convulsions in 50% of mice at an oral ED50 of 15 mg/kg[1].
Kojic amine (8.2-15.7 mg/kg; i.p.; single administration) produces dose-dependent, short-acting analgesic effects in the mouse hot-plate test at 48°C and 55°C, with ED50 values of 9.2 mg/kg and 13.8 mg/kg, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Robidoux Swiss (male, 18-22 g, 3-mercaptopropionic acid-induced convulsions)[1]
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Dosage:15 mg/kg (seizure prevention ED50); 128 mg/kg (acute oral non-lethal)
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Administration:p.o.; single dose (30 mins prior to convulsion induction)
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Result:Prevented tonic extensor seizures in 50% of mice (ED50) challenged with 3-mercaptopropionic acid.
Allowed all mice to survive an acute oral dose of 128 mg/kg.
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Animal Model:albino Swiss CD-1 (male, 18-24 g)[2]
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Dosage:8.2-15.7 mg/kg
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Administration:i.p.; single dose
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Result:Produced dose-dependent, short-acting analgesic effects in the mouse hot-plate test at 48°C and 55°C, with ED50 values of 9.2 mg/kg and 13.8 mg/kg, respectively.
Chemical Information
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CAS No. 68642-64-8
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Masse moléculaire 141.13
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Formule C6H7NO3
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SMILES
O=C1C=C(OC=C1O)CN
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kojic amine Related Classifications
HY-121554 Related Classifications
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