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Cat. No.: HY-19852

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KRP-105

KRP-105 is a potent, highly selective, and orally effective PPAR alpha (EC₅₀ = 8 nM) agonist. KRP-105 can significantly reduce serum triglyceride, total cholesterol, and non high density lipoprotein cholesterol levels. KRP-105 can be used for research on metabolic diseases such as dyslipidemia.

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CAS No.: 876145-69-6
Formule: C₂₃H₂₂ClN₃O₃S
Masse moléculaire:455.96

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

KRP-105 Chemical Structure

CAS No.: 876145-69-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

PPARα

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	0.008 μM Compound: (S)-4f, KRP-105	Transactivation of human PPARalpha expressed in CHO-K1 cells Transactivation of human PPARalpha expressed in CHO-K1 cells	[PMID: 22133631]
CHO-K1	EC₅₀	3 μM Compound: (S)-4f, KRP-105	Transactivation of human PPARdelta expressed in CHO-K1 cells Transactivation of human PPARdelta expressed in CHO-K1 cells	[PMID: 22133631]
CHO-K1	EC₅₀	9.6 μM Compound: (S)-4f, KRP-105	Transactivation of human PPARgamma expressed in CHO-K1 cells Transactivation of human PPARgamma expressed in CHO-K1 cells	[PMID: 22133631]
HEK-293T	EC₅₀	5 nM Compound: SC-1	Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactamase reporter gene assay Agonist activity at GAL4-tagged PPARalpha ligand-binding domain (unknown origin) expressed in HEK293T cells incubated for 16 to 19 hrs by beta-lactamase reporter gene assay	[PMID: 25491112]

Chemical Information

CAS No. 876145-69-6
Masse moléculaire 455.96
Formule C₂₃H₂₂ClN₃O₃S
SMILES

OC(C1=CC=CC(N(CCC2)C[C@H]2NC(C3=C(C)N=C(C4=CC=C(C=C4)Cl)S3)=O)=C1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nomura M, et al. Discovery of cyclic amine-substituted benzoic acids as PPARα agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):334-8. [Content Brief]

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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KRP-105

Voir tous les produits spécifiques à Isoform PPAR

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

KRP-105 Related Classifications

HY-19852 Related Classifications

Bioz

Keywords

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