Linoleylanilide
Linoleylanilide (Linoleic acid anilide) is a Linoleic acid (HY-N0729) derivative. Linoleylanilide slightly inhibits the PMA (HY-18739)-induced expression of CD11b. Linoleylanilide inhibits serum LDH, GOT and GPT activities. Linoleylanilide decreases red cell counts and hemoglobin content.
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- CAS No.: 19878-10-5
- Formule: C24H37NO
- Masse moléculaire:355.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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GPT/ALT |
GOT/AST |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | CC50 |
97.8 μM
Compound: 1g
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Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33479624] |
| THP-1 | IC50 |
21 μM
Compound: 1g
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Inhibition of LPS-induced TNFalpha production in human THP-1 cells incubated for 2 hrs followed by LPS stimulation and measured after 12 hrs by ELISA
Inhibition of LPS-induced TNFalpha production in human THP-1 cells incubated for 2 hrs followed by LPS stimulation and measured after 12 hrs by ELISA
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[PMID: 33479624] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 19878-10-5
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Masse moléculaire 355.56
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Formule C24H37NO
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SMILES
CCCCC/C=C\C/C=C\CCCCCCCC(NC1=CC=CC=C1)=O
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Synonyms
Linoleic acid anilide; LAA
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Khan MF, et al. Heated linoleic acid anilide: toxicity and relevance to toxic oil syndrome. Toxicology. 1991;68(2):143-55. [Content Brief]
[2]. Heiskanen KM, et al. Effect of linoleic acid, linoleic acid anilide, and arachidonic acid on the expression of adhesion molecules on human neutrophils. Arch Toxicol. 1997;71(10):627-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Linoleylanilide Related Classifications
HY-116509 Related Classifications
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