ProTx-III
ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia.
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- CAS No.: 1808297-63-3
- Formule: C162H246N52O43S6
- Masse moléculaire:3802.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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Nav1.7 2.1 nM (IC50) |
ProTx-III in native, recombinant and synthetic C-terminal acid and amide forms inhibit hNaV1.7 with IC50s of 2.1, 9.5, 11.5 and 2.5 nM, respectively[1].
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ProTx-III inhibits hNav1.7 without significantly altering the voltage dependence of activation or inactivation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:OD1-induced mouse model of pain(300Nm; intraplantar injection)[1]
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Dosage:100 nM, 300 nM, 1μM
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Administration:intraplantar injection
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Result:Showed at 1 μM (40 pmoles in a 40 μl injection) and 300 nM (12 pmoles in a 40 μl injection) significantly reduced spontaneous pain behaviour in a concentration dependent manner and this reduction in pain behaviour persisted for 25 min after injection of the highest concentration.
Chemical Information
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CAS No. 1808297-63-3
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Masse moléculaire 3802.40
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Formule C162H246N52O43S6
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Synonyms
μ-TRTX-Tp1a
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Sequence
Asp-Cys-Leu-Lys-Phe-Gly-Trp-Lys-Cys-Asn-Pro-Arg-Asn-Asp-Lys-Cys-Cys-Ser-Gly-Leu-Lys-Cys-Gly-Ser-Asn-His-Asn-Trp-Cys-Lys-Leu-His-Ile-NH2 (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
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Sequence Shortening
DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI-NH2 (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ProTx-III Related Classifications
HY-P5153 Related Classifications
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