PU-20F
PU-20F is a Hsp90 inhibitor with an EC50 of 6.8 μM. PU-20F competes with Geldanamycin (HY-15230) for binding to Hsp90 and regulates the function of this molecular chaperone. PU-20F induces the degradation of oncogenic Her2 tyrosine kinase. PU-20F blocks the growth of breast cancer cells. PU-20F can be used in breast cancer-related research.
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- CAS No.: 422508-29-0
- Formule: C20H24FN5O4
- Masse moléculaire:417.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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HSP90 6.8 μM (EC50) |
PU-20F (compound 59) competes with geldanamycin for binding to purified Hsp90 protein with an EC50 of 6.8 μM[1].
PU-20F (72 h) inhibits the growth of MCF-7 human breast cancer cells with an IC50 of 23 μM[1].
PU-20F induces degradation of Her2 tyrosine kinase in MCF-7 human breast cancer cells with an IC50 of 20 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 422508-29-0
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Masse moléculaire 417.44
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Formule C20H24FN5O4
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SMILES
FC=1N=C(N)C=2N=C(N(C2N1)CC3OCCC3)CC4=CC(OC)=C(OC)C(OC)=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PU-20F Related Classifications
HY-121706 Related Classifications
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