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Cat. No.: HY-16750

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Radalbuvir

(Synonyms: GS-9669)

Radalbuvir (GS-9669) is a non-nucleoside inhibitor of nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp). Radalbuvir shows strong anti-HCV potency (GT1a intrinsic EC₅₀ = 2.9 nM, GT1b EC₅₀ = 6 nM).

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CAS No.: 1314795-11-3
Formule: C₃₀H₄₁NO₆S
Masse moléculaire:543.71

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Radalbuvir Chemical Structure

CAS No.: 1314795-11-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

RNA Polymerase

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	11 nM Compound: 53, GS-9669	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	128 nM Compound: 53, GS-9669	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as plasma adjusted antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as plasma adjusted antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	14 nM Compound: 53, GS-9669	Antiviral activity against HCV genotype 1b harboring NS5B polymerase M423T mutant infected in human HuH7-Lunet cells by luciferase reporter gene assay Antiviral activity against HCV genotype 1b harboring NS5B polymerase M423T mutant infected in human HuH7-Lunet cells by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	2.9 nM Compound: 53, GS-9669	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	6 nM Compound: 53, GS-9669	Antiviral activity against HCV genotype 1b harboring wild type NS5B polymerase infected in human HuH7-Lunet cells by luciferase reporter gene assay Antiviral activity against HCV genotype 1b harboring wild type NS5B polymerase infected in human HuH7-Lunet cells by luciferase reporter gene assay	[PMID: 24144213]
MT4	CC₅₀	>20 μM Compound: 53, GS-9669	Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay	[PMID: 24144213]
MT4	CC₅₀	12138 nM Compound: 53, GS-9669	Intrinsic cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay Intrinsic cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay	[PMID: 24144213]

In Vitro

Radalbuvir (GS-9669) shows high in vitro metabolic stability, long residence time in rats, and maintained high activity against the NS5B M423T mutation (GT1b M423T EC₅₀ = 14 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1314795-11-3
Masse moléculaire 543.71
Formule C₃₀H₄₁NO₆S
SMILES

O=C([C@@H]1CCC(C)=CC1)N([C@H]2CC[C@@](CO[C@H]3CCOC3)(O)CC2)C(C=C(C#CC(C)(C)C)S4)=C4C(O)=O
Synonyms

GS-9669
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhou Z, et al. Small molecule NS5B RdRp non-nucleoside inhibitors for the treatment of HCV infection: A medicinal chemistry perspective. Eur J Med Chem. 2022 Jul 8;240:114595. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Essai clinique
Chemical Information
Pureté et documentation
Références

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Radalbuvir

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Radalbuvir Related Classifications

HY-16750 Related Classifications