Ranatensin
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212),Bradykinin (HY-P0206), or Norepinephrine (HY-13715).
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- CAS No.: 29451-71-6
- Formule: C61H84N16O13S
- Masse moléculaire:1281.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Ranatensin (0.3 nM; 30 min) induces amylase release by various pancreatic secretagogues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ranatensin (10-50 μg/mL, 0.1-1 mL; i.v.; single dose) also lowers blood pressure in the monkey, being as potent as Eledoisin (HY-P0006). It show a direct peripheral action on vascular smooth muscle[2].
Ranatensin (10-50 μg/mL, 0.005-0.1 mL; i.v.; single dose) has a variable effect based on the basal level of blood pressure in the rat that shows antihypertensive efffect during high level and raises blood pressure when level is low, in part due to the release of noradrenaline from peripheral sympathetic nerve endings[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 29451-71-6
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Masse moléculaire 1281.48
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Formule C61H84N16O13S
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Sequence Shortening
Glp-VPQWAVGHFM-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Jensen RT, et al. A synthetic peptide that is a bombesin receptor antagonist. Nature. 1984 May 3-9;309(5963):61-3. [Content Brief]
[2]. Geller RG, et al. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol. 1970 Dec;40(4):605-16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ranatensin Related Classifications
HY-P1685 Related Classifications
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