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Resistomycin

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Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis.

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Pureté: 99.9%
CAS No.: 20004-62-0
Formule: C₂₂H₁₆O₆
Masse moléculaire:376.36

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Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Resistomycin Chemical Structure

CAS No.: 20004-62-0

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Activité biologique
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- Cellular Effect
- In Vitro
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Activité biologique

Description

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis^[1]^[2]^[3]^[4].

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Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	0.5 μM Compound: 1	Antiproliferative activity against human CEM cells after 72 hrs by MTT assay Antiproliferative activity against human CEM cells after 72 hrs by MTT assay	[PMID: 29137865]
CCRF-CEM	IC₅₀	0.5 μM Compound: 5	Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 33974416]
HCT-116	IC₅₀	0.1 μM Compound: 1	Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay	[PMID: 29137865]
HCT-116	IC₅₀	0.3 μM Compound: 1	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 29137865]
HeLa	IC₅₀	0.1 μM Compound: 1	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 29137865]
HeLa	IC₅₀	0.1 μM Compound: 5	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 33974416]
HMEC-1	IC₅₀	0.5 μM Compound: 1	Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay	[PMID: 29137865]
HMEC-1	IC₅₀	0.5 μM Compound: 5	Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 33974416]
K562	IC₅₀	0.3 μM Compound: 1	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 29137865]
L1210	IC₅₀	0.7 μM Compound: 1	Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay	[PMID: 29137865]
L1210	IC₅₀	0.7 μM Compound: 5	Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 33974416]
T-24	IC₅₀	26 μM Compound: 1	Growth inhibition of human T24 cells after 72 hrs by cell impedance method Growth inhibition of human T24 cells after 72 hrs by cell impedance method	[PMID: 29137865]

In Vitro

Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation^[1].
Resistomycin displays a high affinity for GST-Pellino-1 (K_D = 2.58 μM) as indicated by surface plasmon resonance^[1].
Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells^[1].
Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo^[3].