Resolvin E1
Based on 2 publication(s) in Google Scholar
Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production.
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- Pureté: 98.1%
- CAS No.: 552830-51-0
- Formule: C20H30O5
- Masse moléculaire:350.45
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Stockage:
Solution, -20°C, 2 years
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Activité biologique
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Human Endogenous Metabolite |
Resolvin E1 (0.1-100 nM) gives concentration-dependent inhibition of TNF-α–induced NF-κB activation with an EC50 of ～1.0 nM in ChemR23-transfected cells. Resolvin E1 (100 nM) increases phosphorylation of extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase both in peripheral blood monocytes and HEK-ChemR23 cells[2]. Resolvin E1 specifically interacts with the LTB4 receptor BLT1 on neutrophils and ChemR23 on monocytes to regulate leukocytes during inflammation. Resolvin E1 also stimulates the uptake and clearance of local cytokine[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6- to 8-week-old female BALB/c mice (TNBS colitis model)[1]
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Dosage:1.0 μg per mouse; 50 μg/kg
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Administration:i.p.; on days -8, -1, and 0 before the induction of colitis
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Result:Reduced overall mortality, which was 25% and 62.5% at 1.0 μg per mouse and 50 μg/kg, respectively.
Chemical Information
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CAS No. 552830-51-0
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Appearance Liquid
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Masse moléculaire 350.45
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Formule C20H30O5
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Color Colorless to light yellow
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SMILES
CC[C@@H](O)/C=C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
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Synonyms
RvE1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Solution, -20°C, 2 years
Publications (2)
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Journal Impact Factor
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Most Recent
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Exp Neurol
RvE1/ChemR23 facilitates hematoma clearance and promotes M2 polarization of macrophages/microglia in intracerebral hemorrhage. [Abstract]2025 Jan 30:115173. PMID: 39892453 -
Immunol Invest
Resolvin E1 and Inhibition of BLT2 Signaling Attenuate the Inflammatory Response and Improve One-Lung Ventilation-Induced Lung Injury. [Abstract]2024 Sep 4:1-15. PMID: 39230105
Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]
Pathological alterations in lung tissues analyzed via H&E staining with Resolvin E1 (RvE1) treatment.
Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]
Expression levels of apoptotic markers Bax, bcl-2, and caspase-3 were evaluated through Western blot analysis with Resolvin E1 (RvE1) treatment.
Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]
Apoptosis in lung tissues quantified via TUNEL staining with Resolvin E1 (RvE1) treatment.
Resolvin E1 purchased from MedChemExpress. Usage Cited in: Immunol Invest. 2024 Sep 4:1-15. [Abstract]
Quantification of inflammatory cytokines IL-8, tnf-α, IL-1β, GM-CSF (CSF2, colony stimulating factor 2), KC (CXCL1, chemokine ligand 1), MCP-1 (CCL2, Monocyte Chemotactic and activating factor), MIP-2 (CXCL2, chemokine ligand 2), and IL-6, as determined by ELISA with Resolvin E1 (RvE1) treatment.
Pureté et documentation
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Fiche technique (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Arita M, et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7671-6. [Content Brief]
[2]. Schwab JM, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007 Jun 14;447(7146):869-74. [Content Brief]
[3]. Hasturk H, et al. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissuehomeostasis in vivo. J Immunol. 2007 Nov 15;179(10):7021-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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