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Cat. No.: HY-144645

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SP-471P

Name: SP-471P
Brand: MedChemExpress
SKU: HY-144645
Price: 425.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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SP-471P is a potent dengue virus (DENV) protease inhibitor with EC₅₀s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC₅₀ value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.

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Pureté: 99.46%
CAS No.: 2768011-36-3
Formule: C₃₃H₂₆BrN₅O₂
Masse moléculaire:604.50

Stockage:

Store at room temperature, keep dry and cool.

In solvent -80°C, 1 year , -20°C, 6 months

SP-471P Chemical Structure

CAS No.: 2768011-36-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

EC₅₀: 5.9 μM (DENV1), 1.4 μM (DENV2), 5.1 μM (DENV3), 1.7 μM (DENV4)^[1]

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>100 μM Compound: 32a; SP-471P	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability	[PMID: 34298282]
PBMC	CC₅₀	>100 μM Compound: 32a; SP-471P	Cytotoxicity against human PBMC assessed as reduction in cell viability Cytotoxicity against human PBMC assessed as reduction in cell viability	[PMID: 34298282]

In Vitro

SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC₅₀s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively^[1].
SP-471P (10 μM; 48 hours) exhibits an EC₅₀ value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells^[1].
SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2^[1].
SP-471P (10 μM; 30 hours) targets the NS3_int cleavage site of DENV in DENV2-infected Huh7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:

Human peripheral blood mononuclear cells (infected with ADE)^[1]
Concentration:

10 μM
Incubation Time:

48 hours
Result:

Resulted in an EC₅₀ value of 1.5 μM for ADE infection in human PBMCs.

RT-PCR

Cell Line:

Huh7 (infected with DENV2 at MOI 1 for 6 hours)^[1]
Concentration:

10 μM
Incubation Time:

6-54 hours
Result:

Reduced viral RNA synthesis.

Western Blot Analysis

Cell Line:

Huh7 (infected with DENV2 at MOI 1 for 6 hours)^[1]
Concentration:

10 μM
Incubation Time:

30 hours
Result:

Targeted the NS3_int cleavage site of DENV.

Chemical Information

CAS No. 2768011-36-3
Appearance Solid
Masse moléculaire 604.50
Formule C₃₃H₂₆BrN₅O₂
Color White to off-white
SMILES

N/C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(/C(N)=N/O)=C6)=C4)=C2)=C1)=N\O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Swarbrick C, Zogali V, Chan KWK, et al. Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease. Eur J Med Chem. 2021;224:113695. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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SP-471P

NS2B/NS3-IN-2

SP-471

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis