T7117
T7117 is a TRIM25-HIF-1α inhibitor. T7117 disrupts the interaction between TRIM25-HIF-1α. T7117 can be used for the research of glioblastoma.
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- CAS No.: 162060-03-9
- Formule: C9H15N5O3
- Masse moléculaire:241.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Activité biologique
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HIF-1α |
T7117 (1-10 mM; 5 days) inhibits the proliferation of U251 and U118 glioblastoma cells[1].
T7117 disrupts the TRIM25-HIF-1α interaction in U251, U118, and 293T cells, inhibits TRIM25-mediated HIF-1α stabilization and ubiquitination in a K532-dependent manner, and reduces HIF-1α protein levels in U251 and U118 glioblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U251, U118
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Concentration:1 mM; 10 mM
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Incubation Time:5 days
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Result:Significantly inhibited the proliferation of U251 and U118 GBM cells at 1 mM.
Exerted significant inhibitory effects on GBM cell proliferation at 10 mM, with effects comparable to those of T17056 and greater than other tested compounds.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (4-week-old female, 12-16g, intracranial implantation of 5×105 glioblastoma cells)[1]
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Dosage:10 μg
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Administration:i.p.; every 2 days
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Result:Inhibited intracranial tumor growth as measured by bioluminescent imaging.
Prolonged survival time of mice bearing luciferase-labeled U251 tumors.
Reduced tumor cell proliferation as shown by Ki-67 staining of tumor sections.
Caused no significant treatment-related toxicity, with stable body weight and no histopathological abnormalities in liver, lung, and kidney.
Chemical Information
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CAS No. 162060-03-9
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Masse moléculaire 241.25
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Formule C9H15N5O3
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SMILES
C[C@H]([C@H]([C@@H]1CNC2=C(C(N=C(N2)N)=O)N1)O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T7117 Related Classifications
HY-183638 Related Classifications
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