TG6-129
TG6-129 is a selective antagonist of the EP2 receptor. TG6-129 reduces the expression of inflammatory factors induced by butaprost in P388D1 macrophages.
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- CAS No.: 1164464-14-5
- Formule: C20H18FN5O3S3
- Masse moléculaire:491.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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EP |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C6 | CC50 |
326 μM
Compound: 1, TG6-129, 17503974
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Cytotoxicity against rat C6 cells after 48 hrs
Cytotoxicity against rat C6 cells after 48 hrs
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[PMID: 23914286] |
| C6 | IC50 |
1.6 μM
Compound: 1, TG6-129, 17503974
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Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay
Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay
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[PMID: 23914286] |
Chemical Information
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CAS No. 1164464-14-5
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Masse moléculaire 491.58
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Formule C20H18FN5O3S3
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SMILES
O=C(NC(NC1=CC=C(S(=O)(NC2=NN=C(CC)S2)=O)C=C1)=S)/C=C/C3=CC=C(F)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TG6-129 Related Classifications
HY-18970 Related Classifications
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