UBP296
UBP296 is a potent and selective antagonist of GLUK5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices.
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- CAS No.: 745055-86-1
- Formule: C15H15N3O6
- Masse moléculaire:333.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
IC50: 3.5 ± 1.5 μM (GLUK5), 4.0 ± 0.7 μM (GLUK5/GLUK6), 7.0 ± 5.1 μM (GLUK5/GLUK2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
880 μM
Compound: 38a
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Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cells
Displacement of [3H]kainate from human GLUK7 receptor expressed in HEK293 cells
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[PMID: 16302825] |
Chemical Information
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CAS No. 745055-86-1
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Masse moléculaire 333.30
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Formule C15H15N3O6
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SMILES
O=C(N(C=CC1=O)CC(N)C(O)=O)N1CC2=C(C=CC=C2)C(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UBP296 Related Classifications
HY-107605 Related Classifications
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