USP10-IN-3
Based on 1 Customer Validation
USP10-IN-3 (compound D1) is a potent USP10 inhibitor with an IC50 value of 7.2 µM. USP10-IN-3 inhibits cell proliferation. USP10-IN-3 induces apoptosis and cell cycle arrest at S-phase.
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- Pureté: 98.00%
- CAS No.: 3059565-11-3
- Formule: C29H25ClN4O3
- Masse moléculaire:512.99
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Ubiquitination Compound Library
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Protease Inhibitor Library
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
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High-Throughput Bioactive Compound Library
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Apoptosis Compound Library
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
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Anti-Aging Compound Library
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Activité biologique
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USP10 7.2 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| Bel-7402 | IC50 |
2.3 μM
Compound: D1
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Antiproliferative activity against human Bel-7402 cells by CCK-8 method
Antiproliferative activity against human Bel-7402 cells by CCK-8 method
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[PMID: 38718626] |
USP10-IN-3 (compound D1) (0-100 µM) inhibits cell proliferation with an IC50 value of 2.3 µM for Huh-7 cells[1].
USP10-IN-3 (compound D1) (0-10 µM; 24 h) induces apoptosis and cell cycle arrest at S-phase in a dose-dependent manner[1].
USP10-IN-3 (compound D1) (0-30 µM; 24 h) decreases the expression of YAP1, p53, p21 in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7 cells
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Concentration:0, 0.625, 1.25, 2.5, 5, 10 µM
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Incubation Time:24 h
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Result:Induced apoptosis in a dose-dependent manner.
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Cell Line:Huh-7 cells
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Concentration:0, 0.625, 1.25, 2.5, 5 µM
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Incubation Time:24 h
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Result:Induced cell cycle arrest at S-phase.
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Cell Line:Huh-7 cells
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Concentration:0, 0.37, 1.1, 3.3, 10, 30 µM
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Incubation Time:24 h
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Result:Decreased the expression of YAP1, p53, p21 in a dose-dependent manner.
Chemical Information
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CAS No. 3059565-11-3
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Appearance Solid
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Masse moléculaire 512.99
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Formule C29H25ClN4O3
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Color White to off-white
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SMILES
CC1=CC=C2C(C(C3=NC(C4=C(C=CC=C4)C)=NO3)=CN(C2=C1)CC(NCCC5=CC=C(C=C5)Cl)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 5 mg/mL (9.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9494 mL | 9.7468 mL | 19.4936 mL | 48.7339 mL |
| 5 mM | 0.3899 mL | 1.9494 mL | 3.8987 mL | 9.7468 mL |
USP10-IN-3 Related Classifications
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