Zinc borate
Based on 1 Customer Validation
Zinc borate is a bioactive inorganic substance with properties including osteogenic induction, pro-angiogenesis, antioxidation, antimutagenesis and cytotoxicity. In the field of bone tissue engineering, Zinc borate is often incorporated into chitosan scaffolds. By releasing zinc ions and borate ions, Zinc borate induces the differentiation of human dental pulp stem cells into osteoblasts, upregulates the expression of bone-related genes and promotes calcium deposition. Zinc borate also promotes angiogenesis by upregulating key factors such as vascular endothelial growth factor. Zinc borate exhibits antioxidant capacity to scavenge free radicals, and can specifically reduce mutagenicity under specific conditions. Zinc borate reduces the survival rate of mouse fibroblasts, but it can still be used in studies related to bone tissue engineering.
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- CAS No.: 1332-07-6
- Formule: Zn3(BO3)2
- Masse moléculaire:313.76
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Stockage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Activité biologique
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RUNX2 |
When zinc borate (1.0% (w/v); 7-21 d) is loaded on chitosan scaffolds, it supports stem cells from human exfoliated deciduous teeth (SHEDs), significantly improving cell viability, with absorbance values at 570 nm of approximately 0.29, 0.41, and 0.57, respectively; it also significantly upregulates ALP activity[1].
Zinc borate (1.0% (w/v); 7-21 d) incorporated into chitosan scaffolds supports SHEDs, significantly upregulating the expression of osteogenesis-related genes (Runx2, OPN, and OCN) and angiogenesis-related genes (VEGF, Ang-1) during osteogenic differentiation[1].
Zinc borate (1 mg/mL; 30 min) exhibits low DPPH free radical scavenging activity in cell-free assays, with an inhibition rate of 13.50% at 1 mg/mL[2].
Zinc borate (0.04-0.2 mg; 72 h) exhibits low antimutagenic activity against 4-NPD-induced mutagenicity in Salmonella typhimurium strain TA98, but shows no antimutagenic activity against sodium azide-induced mutagenicity in strain TA100[2].
Zinc borate (0.3-76.19 μg/mL; 24-72 h) exhibits cytotoxicity against mouse fibroblast L929 cells, with an IC50 value of 40.70 μg/mL at 24 h and 32.93 μg/mL at 72 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:stem cells from human exfoliated deciduous teeth (SHEDs)
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Concentration:1.0% (w/v)
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Incubation Time:7, 14, 21 days (cell culture); 45 cycles (RT-PCR)
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Result:Showed the highest expression of Runx2 after 14 days of culture.
Showed the highest expression of OPN and OCN after 21 days of culture.
Exhibited high expression of VEGF and Ang-1 across culture time points.
Had all gene expression levels significantly higher than those in pure chitosan scaffolds.
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Cell Line:stem cells from human exfoliated deciduous teeth (SHEDs)
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Concentration:1.0% (w/v)
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Incubation Time:7, 21 days (cell culture); 1 h (primary antibody incubation); 1 h (secondary antibody incubation)
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Result:Showed notable expression of the early osteoblastic marker BMP-2 after 7 days of culture.
Showed notable expression of the late osteoblastic marker OCN after 21 days of culture.
Chemical Information
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CAS No. 1332-07-6
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Appearance Solid
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Masse moléculaire 313.76
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Formule Zn3(BO3)2
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Color White to off-white
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SMILES
O=BB(OO[Zn])OOO[Zn][Zn]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Pureté et documentation
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Fiche technique (274 KB)
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SDS (788 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zinc borate Related Classifications
HY-W115785 Related Classifications
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- Zinc borate
- 1332-07-6
- Environmental Pollutants
- RUNX
- VEGFR
- SHEDs
- DPPH free radicals
- vascular endothelial growth factor
- 4-nitro-o-phenylenediamine
- chitosan scaffolds
- Salmonella typhimurium TA98 strain
- mouse fibroblast cells
- Salmonella typhimurium TA100 strain
- human dental stem cells
- angiopoietin-1
- Inhibitor
- inhibitor
- inhibit