2. Anti-infection
  3. HIV
  4. Claficapavir

Claficapavir  (Synonyms: A1752)

Cat. No.: HY-145560 Purity: 99.14%
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Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1.

For research use only. We do not sell to patients.

Claficapavir Chemical Structure

Claficapavir Chemical Structure

CAS No. : 2055732-24-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mg USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

Claficapavir Related Antibodies

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Description

Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1[1].

IC50 & Target[1]

HIV-1

 

In Vitro

Claficapavir binds directly to HIV-1 NC, thereby inhibiting specific chaperone functions of NC including Psi RNA dimerization and complementary trans-activation response element (cTAR) DNA destabilization, and it also disrupts the proper Gag processing[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Claficapavir Related Antibodies
Molecular Weight

393.86

Formula

C17H12ClNO4S2
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(N(C(S/1)=S)CCC(O)=O)C1=C\C2=CC=C(C3=CC=C(C=C3)Cl)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (507.79 mM; ultrasonic and warming and heat to 40°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5390 mL 12.6949 mL 25.3897 mL
5 mM 0.5078 mL 2.5390 mL 5.0779 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5390 mL 12.6949 mL 25.3897 mL 63.4743 mL
5 mM 0.5078 mL 2.5390 mL 5.0779 mL 12.6949 mL
10 mM 0.2539 mL 1.2695 mL 2.5390 mL 6.3474 mL
15 mM 0.1693 mL 0.8463 mL 1.6926 mL 4.2316 mL
20 mM 0.1269 mL 0.6347 mL 1.2695 mL 3.1737 mL
25 mM 0.1016 mL 0.5078 mL 1.0156 mL 2.5390 mL
30 mM 0.0846 mL 0.4232 mL 0.8463 mL 2.1158 mL
40 mM 0.0635 mL 0.3174 mL 0.6347 mL 1.5869 mL
50 mM 0.0508 mL 0.2539 mL 0.5078 mL 1.2695 mL
60 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0579 mL
80 mM 0.0317 mL 0.1587 mL 0.3174 mL 0.7934 mL
100 mM 0.0254 mL 0.1269 mL 0.2539 mL 0.6347 mL
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Claficapavir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Claficapavir2055732-24-4A1752A 1752A-1752HIVHuman immunodeficiency virusHIV-1nucleocapsid proteinchaperonePsi RNA dimerizationInhibitorinhibitorinhibit

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