CLX-0921
CLX-0921 is an orally active PPARγ agonist with an IC50 of 1.54 μM. CLX-0921 has a potent antihyperglycemic activity, and can be used for the study of type 2 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 249886-47-3
- Formula: C28H25NO7S
- Molecular Weight:519.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PPARγ 1.54 μM (IC50) |
CLX-0921 (0.01 M, 0.1 M, 1.0 M, and 10 M) increases glucose uptake in 3T3-L1 adipocytes. CLX-0921 has potent antihyperglycemic activity with low adipogenic potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/KsJ-db/db and C57BL/6J-ob/ob mice (7-week-old)[1]
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Dosage:3.1 mg/kg, 6.3 mg/kg, and 12.5 mg/kg
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Administration:Oral gavage; once daily; for 19 days
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Result:Showed dose-dependent antihyperglycemic activity.
Chemical Information
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CAS No. 249886-47-3
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Molecular Weight 519.57
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Formula C28H25NO7S
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SMILES
O=C(OC)/C(C1=CC=C(OC2=CC=C(CC(SC(N3)=O)C3=O)C=C2)C=C1)=C/C4=CC(OC)=CC(OC)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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