CN045
CN045 is a blood-brain barrier-permeable, selective M1 muscarinic receptor ligand with an IC50 value of 1 μM. CN045 enhances remyelination in mouse brain regions. CN045 can be used in studies related to multiple sclerosis.
For research use only. We do not sell to patients.
- CAS No.: 401809-27-6
- Formula: C16H22Cl3NO2
- Molecular Weight:366.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mAChR1 1 μM (IC50) |
CN045 (5 days) potently promotes differentiation of primary mouse PLP-EGFP transgenic oligodendrocyte progenitor cells in vitro with an EC50 of 40 nM, yielding a higher percentage of mature oligodendrocytes than Clemastine (HY-B0298)[1].
CN045 (5 days) potently stimulates differentiation of primary mouse OPCs into mature, myelin protein-expressing oligodendrocytes with an EC50 of 0.04 μM[2].
CN045 (1 μM; 14 days) promotes myelin-like ensheathment of engineered nanofibers by primary mouse OPCs, increasing both oligodendrocyte numbers and ensheathment length[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57/BL/6J (8-week-old male; multiple sclerosis model via 12 weeks of 0.3% cuprizone chow plus daily i.p. sirolimus 10 mg/kg-induced demyelination)[2]
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Dosage:10 mg/kg
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Administration:i.p.; daily; 6 weeks
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Result:Increased remyelination in the corpus callosum, hippocampus, and cerebral cortex compared to vehicle treatment.
Increased the number of PPD+ myelinated axons per unit area in the corpus callosum.
Increased the percentage area of PLP staining in the hippocampus.
Increased the percentage area of PLP staining in the cerebral cortex.
Chemical Information
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CAS No. 401809-27-6
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Molecular Weight 366.71
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Formula C16H22Cl3NO2
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SMILES
ClC1=C(OCCOCCN2CCC(C)CC2)C(Cl)=CC(Cl)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CN045 Related Classifications
HY-187683 Related Classifications
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