CRBN ligand-394
Based on 1 Customer Validation
CRBN ligand-394 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-394 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 2641512-77-6
- Formula: C15H20ClN3O2
- Molecular Weight:309.79
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2641512-77-6
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Appearance Solid
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Molecular Weight 309.79
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Formula C15H20ClN3O2
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Color White to off-white
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SMILES
Cl.O=C1NC(=O)C(C2=CC=C(C=C2)N3CCNCC3)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMSO : 100 mg/mL (322.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (243 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2280 mL | 16.1400 mL | 32.2799 mL | 80.6998 mL |
| 5 mM | 0.6456 mL | 3.2280 mL | 6.4560 mL | 16.1400 mL | |
| 10 mM | 0.3228 mL | 1.6140 mL | 3.2280 mL | 8.0700 mL | |
| 15 mM | 0.2152 mL | 1.0760 mL | 2.1520 mL | 5.3800 mL | |
| 20 mM | 0.1614 mL | 0.8070 mL | 1.6140 mL | 4.0350 mL | |
| 25 mM | 0.1291 mL | 0.6456 mL | 1.2912 mL | 3.2280 mL | |
| 30 mM | 0.1076 mL | 0.5380 mL | 1.0760 mL | 2.6900 mL | |
| 40 mM | 0.0807 mL | 0.4035 mL | 0.8070 mL | 2.0175 mL | |
| 50 mM | 0.0646 mL | 0.3228 mL | 0.6456 mL | 1.6140 mL | |
| 60 mM | 0.0538 mL | 0.2690 mL | 0.5380 mL | 1.3450 mL | |
| 80 mM | 0.0403 mL | 0.2017 mL | 0.4035 mL | 1.0087 mL | |
| 100 mM | 0.0323 mL | 0.1614 mL | 0.3228 mL | 0.8070 mL |
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