2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-394

CRBN ligand-394 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-394 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-394

CRBN ligand-394 Chemical Structure

CAS No. : 2641512-77-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
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1 g In-stock
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CRBN ligand-394 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-394 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-394 can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRBN ligand-394 Related Antibodies
Molecular Weight

309.79

Formula

C15H20ClN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

Cl.O=C1NC(=O)C(C2=CC=C(C=C2)N3CCNCC3)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (322.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2280 mL 16.1400 mL 32.2799 mL
5 mM 0.6456 mL 3.2280 mL 6.4560 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2280 mL 16.1400 mL 32.2799 mL 80.6998 mL
5 mM 0.6456 mL 3.2280 mL 6.4560 mL 16.1400 mL
10 mM 0.3228 mL 1.6140 mL 3.2280 mL 8.0700 mL
15 mM 0.2152 mL 1.0760 mL 2.1520 mL 5.3800 mL
20 mM 0.1614 mL 0.8070 mL 1.6140 mL 4.0350 mL
25 mM 0.1291 mL 0.6456 mL 1.2912 mL 3.2280 mL
30 mM 0.1076 mL 0.5380 mL 1.0760 mL 2.6900 mL
40 mM 0.0807 mL 0.4035 mL 0.8070 mL 2.0175 mL
50 mM 0.0646 mL 0.3228 mL 0.6456 mL 1.6140 mL
60 mM 0.0538 mL 0.2690 mL 0.5380 mL 1.3450 mL
80 mM 0.0403 mL 0.2017 mL 0.4035 mL 1.0087 mL
100 mM 0.0323 mL 0.1614 mL 0.3228 mL 0.8070 mL
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CRBN ligand-394 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-3942641512-77-6CRBN ligand394CRBN ligand 394Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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