2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-397

CRBN ligand-397 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-397 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-397

CRBN ligand-397 Chemical Structure

CAS No. : 2736511-32-1

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10 mM * 1 mL in DMSO
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CRBN ligand-397 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-397 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-397 can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRBN ligand-397 Related Antibodies
Molecular Weight

300.36

Formula

C17H20N2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=CC1CCN(C2=CC=C(C=C2)C3C(=O)NC(=O)CC3)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (332.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3293 mL 16.6467 mL 33.2934 mL
5 mM 0.6659 mL 3.3293 mL 6.6587 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.77%

SDS (394 KB)

COA (247 KB) HNMR (140 KB) RP-HPLC (137 KB) LCMS (232 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3293 mL 16.6467 mL 33.2934 mL 83.2335 mL
5 mM 0.6659 mL 3.3293 mL 6.6587 mL 16.6467 mL
10 mM 0.3329 mL 1.6647 mL 3.3293 mL 8.3233 mL
15 mM 0.2220 mL 1.1098 mL 2.2196 mL 5.5489 mL
20 mM 0.1665 mL 0.8323 mL 1.6647 mL 4.1617 mL
25 mM 0.1332 mL 0.6659 mL 1.3317 mL 3.3293 mL
30 mM 0.1110 mL 0.5549 mL 1.1098 mL 2.7744 mL
40 mM 0.0832 mL 0.4162 mL 0.8323 mL 2.0808 mL
50 mM 0.0666 mL 0.3329 mL 0.6659 mL 1.6647 mL
60 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.3872 mL
80 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0404 mL
100 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.8323 mL
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CRBN ligand-397 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-3972736511-32-1CRBN ligand397CRBN ligand 397Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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