CRBN ligand-547

Cat. No.: HY-W593975 Purity: 99.67%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

CRBN ligand-547 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-547 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-547 Chemical Structure

CAS No. : 2446913-88-6

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-547 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-547 can be linked to a target protein ligand via a linker to form a PROTAC.

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

323.15

Formula

C₁₂H₁₁BrN₄O₂

CAS No.

2446913-88-6

Appearance

Solid

Color

Off-white to light brown

SMILES

O=C1NC(=O)CCN1C2=NN(C=3C=C(Br)C=CC23)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (77.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0945 mL	15.4727 mL	30.9454 mL
5 mM	0.6189 mL	3.0945 mL	6.1891 mL
10 mM	0.3095 mL	1.5473 mL	3.0945 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (248 KB) SDS (393 KB)

COA (255 KB) HNMR (131 KB) RP-HPLC (224 KB) LCMS (350 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0945 mL	15.4727 mL	30.9454 mL	77.3635 mL
	5 mM	0.6189 mL	3.0945 mL	6.1891 mL	15.4727 mL
	10 mM	0.3095 mL	1.5473 mL	3.0945 mL	7.7363 mL
	15 mM	0.2063 mL	1.0315 mL	2.0630 mL	5.1576 mL
	20 mM	0.1547 mL	0.7736 mL	1.5473 mL	3.8682 mL
	25 mM	0.1238 mL	0.6189 mL	1.2378 mL	3.0945 mL
	30 mM	0.1032 mL	0.5158 mL	1.0315 mL	2.5788 mL
	40 mM	0.0774 mL	0.3868 mL	0.7736 mL	1.9341 mL
	50 mM	0.0619 mL	0.3095 mL	0.6189 mL	1.5473 mL
	60 mM	0.0516 mL	0.2579 mL	0.5158 mL	1.2894 mL

CRBN ligand-547 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-5472446913-88-6CRBN ligand547CRBN ligand 547Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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CRBN ligand-547

CRBN ligand-547 Related Antibodies

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