CRBN ligand-547
Based on 1 Customer Validation
CRBN ligand-547 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-547 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 2446913-88-6
- Formula: C12H11BrN4O2
- Molecular Weight:323.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2446913-88-6
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Appearance Solid
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Molecular Weight 323.15
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Formula C12H11BrN4O2
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Color Off-white to light brown
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SMILES
O=C1NC(=O)CCN1C2=NN(C=3C=C(Br)C=CC23)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (77.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (248 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.0945 mL | 15.4727 mL | 30.9454 mL | 77.3635 mL |
| 5 mM | 0.6189 mL | 3.0945 mL | 6.1891 mL | 15.4727 mL | |
| 10 mM | 0.3095 mL | 1.5473 mL | 3.0945 mL | 7.7363 mL | |
| 15 mM | 0.2063 mL | 1.0315 mL | 2.0630 mL | 5.1576 mL | |
| 20 mM | 0.1547 mL | 0.7736 mL | 1.5473 mL | 3.8682 mL | |
| 25 mM | 0.1238 mL | 0.6189 mL | 1.2378 mL | 3.0945 mL | |
| 30 mM | 0.1032 mL | 0.5158 mL | 1.0315 mL | 2.5788 mL | |
| 40 mM | 0.0774 mL | 0.3868 mL | 0.7736 mL | 1.9341 mL | |
| 50 mM | 0.0619 mL | 0.3095 mL | 0.6189 mL | 1.5473 mL | |
| 60 mM | 0.0516 mL | 0.2579 mL | 0.5158 mL | 1.2894 mL |
CRBN ligand-547 Related Classifications
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