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Cat. No.: HY-183818

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CRBN ligand-903

CRBN ligand-903 is a CRBN-binding ligand as well as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase). CRBN ligand-903 can be used to synthesize PROTAC CBP/P300 Degrader-4 (HY-183802).

For research use only. We do not sell to patients.

Formula: C₁₆H₁₄N₂O₅
Molecular Weight:314.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CRBN ligand-903 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

CRBN ligand-903 is a CRBN-binding ligand as well as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase). CRBN ligand-903 can be used to synthesize PROTAC CBP/P300 Degrader-4 (HY-183802)^[1].

IC₅₀ & Target^[1]

Cereblon

All Ligands for E3 Ligase Isoforms :

In Vitro

CRBN ligand-903 (Compound 28e) serves as a building block for the synthesis of PROTAC CBP/P300 Degrader-4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 314.29
Formula C₁₆H₁₄N₂O₅
SMILES

O=C1N(CCC(N1)=O)C(C=C2C(O)=O)=C3C(C=CC=C3)=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Asem MS, et al. Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies. Nat Commun. Published online May 6, 2026. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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