Curcumin-β-D-glucuronide
Based on 1 Customer Validation
Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 227466-72-0
- Formula: C27H28O12
- Molecular Weight:544.50
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c/AnNCr j‐nu/nude mice (6 weeks) were transplanted KRASm/TP53w HCT116 cells[1]
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Dosage:90 mg/kg
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Administration:I.p. thrice a week for 3 weeks
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Result:Suppressed tumor growth by 38%.
Did not show a negative impact on body weight.
Attenuated NF‐κB activity.
Chemical Information
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CAS No. 227466-72-0
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Appearance Solid
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Molecular Weight 544.50
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Formula C27H28O12
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Color Yellow to brown
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SMILES
COC(C=C(C=C1)/C=C/C(CC(/C=C/C2=CC(OC)=C(C=C2)O)=O)=O)=C1O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (91.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Ozawa-Umeta H, et, al. Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo. Cancer Sci. 2020 May;111(5):1785-1793. [Content Brief]
[2]. Ozawa H, et, al. Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood. Biol Pharm Bull. 2017;40(9):1515-1524. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8365 mL | 9.1827 mL | 18.3655 mL | 45.9137 mL |
| 5 mM | 0.3673 mL | 1.8365 mL | 3.6731 mL | 9.1827 mL | |
| 10 mM | 0.1837 mL | 0.9183 mL | 1.8365 mL | 4.5914 mL | |
| 15 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0609 mL | |
| 20 mM | 0.0918 mL | 0.4591 mL | 0.9183 mL | 2.2957 mL | |
| 25 mM | 0.0735 mL | 0.3673 mL | 0.7346 mL | 1.8365 mL | |
| 30 mM | 0.0612 mL | 0.3061 mL | 0.6122 mL | 1.5305 mL | |
| 40 mM | 0.0459 mL | 0.2296 mL | 0.4591 mL | 1.1478 mL | |
| 50 mM | 0.0367 mL | 0.1837 mL | 0.3673 mL | 0.9183 mL | |
| 60 mM | 0.0306 mL | 0.1530 mL | 0.3061 mL | 0.7652 mL | |
| 80 mM | 0.0230 mL | 0.1148 mL | 0.2296 mL | 0.5739 mL |
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