Cyclo(KLARLLT)
Cyclo (KLARLLT) is an EGFR ligand with a Kd value of 1.16 μM. Cyclo (KLARLLT) binds to domain I of EGFR and interacts with both the open and closed conformations of EGFR. Cyclo (KLARLLT) is a modified variant of LARLLT (HY-P11078). Cyclo (KLARLLT) can be used in the research of colorectal cancer.
For research use only. We do not sell to patients.
- Formula: C37H69N11O8
- Molecular Weight:796.01
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
Cyclo (KLARLLT) (0-200 μM) binds to the purified extracellular domain of EGFR, with a KD value of 1.16 μM[1].
Cyclo (KLARLLT) binds to domain I of EGFR (including both open and closed conformations), and its low-energy structure is stabilized by hydrogen bonds and hydrophobic interactions[1].
Cyclo (KLARLLT) (2 mg/mL; 0-48 h at 37°C) exhibits significantly improved stability in human serum compared with its linear analog KLARLLT; nearly 60% of the peptide remains intact after incubation at 37°C for 48 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 796.01
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Formula C37H69N11O8
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Sequence
Cyclo(Lys-Leu-Ala-Arg-Leu-Leu-Thr)
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Sequence Shortening
Cyclo(KLARLLT)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyclo(KLARLLT) Related Classifications
HY-P11752 Related Classifications
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