Cyclo(KLARLLT) 

Cyclo (KLARLLT) is an EGFR ligand with a K_d value of 1.16 μM. Cyclo (KLARLLT) binds to domain I of EGFR and interacts with both the open and closed conformations of EGFR. Cyclo (KLARLLT) is a modified variant of LARLLT (HY-P11078). Cyclo (KLARLLT) can be used in the research of colorectal cancer^[1].

Cyclo (KLARLLT) (0-200 μM) binds to the purified extracellular domain of EGFR, with a K_D value of 1.16 μM^[1].
Cyclo (KLARLLT) binds to domain I of EGFR (including both open and closed conformations), and its low-energy structure is stabilized by hydrogen bonds and hydrophobic interactions^[1].
Cyclo (KLARLLT) (2 mg/mL; 0-48 h at 37°C) exhibits significantly improved stability in human serum compared with its linear analog KLARLLT; nearly 60% of the peptide remains intact after incubation at 37°C for 48 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

796.01

C₃₇H₆₉N₁₁O₈

Cyclo(Lys-Leu-Ala-Arg-Leu-Leu-Thr)

Cyclo(KLARLLT)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Williams TM, et al. Peptide ligands for targeting the extracellular domain of EGFR: Comparison between linear and cyclic peptides. Chem Biol Drug Des. 2018;91(2):605-619.