Cyclo(-RGDfK), 5/6 FAM labeled TFA
Based on 1 Customer Validation
Cyclo(-RGDfK), 5/6 FAM labeled TFA is a Cyclo(-RGDfK) TFA (HY-P0023A) labeled with 5/6 FAM. Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.
For research use only. We do not sell to patients.
- Formula: C48H51N9O13·xC2HF3O2
- Molecular Weight:961.97 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 0.94 nM (αvβ3 integrin)[1]
Chemical Information
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Appearance Solid
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Molecular Weight 961.97 (free base)
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Formula C48H51N9O13·xC2HF3O2
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Sequence
Cyclo(Arg-Gly-Asp-{dPhe}-Lys(5/6 FAM))
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Sequence Shortening
Cyclo(RGD-{dPhe}-Lys(5/6 FAM))
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. [Content Brief]
[2]. Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyclo(-RGDfK), 5/6 FAM labeled TFA Related Classifications
HY-P0023F1 Related Classifications
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