1. Antibody-drug Conjugate/ADC Related
  2. ADC Cytotoxin
  3. DC44SMe

DC44SMe 

Cat. No.: HY-135124
Handling Instructions

DC44SMe, a phosphate prodrug of cytotoxic DNA alkylator DC44, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer.

For research use only. We do not sell to patients.

DC44SMe Chemical Structure

DC44SMe Chemical Structure

CAS No. : 1354787-76-0

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Description

DC44SMe, a phosphate prodrug of cytotoxic DNA alkylator DC44, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer[1].

In Vitro

The phosphate prodrug may be a suitable choice for ADCs of effector molecules that do not possess sufficient water solubility or stability[1].

Molecular Weight

806.29

Formula

C₃₈H₃₇ClN₅O₇PS₂

CAS No.

1354787-76-0

SMILES

O=C(C(N1)=CC2=C1C=CC(NC(CCC(SSC)(C)C)=O)=C2)NC3=CC4=C(NC(C(N5C[[email protected]@H](CCl)C6=C5C=C(OP(O)(O)=O)C7=CC=CC=C67)=O)=C4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DC44SMeADC CytotoxinPhosphateprodrugcytotoxicDNAalkylatorRamosNamalwaHL60/scancercell targetedtreatmentInhibitorinhibitorinhibit

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