D-Sorbitol-d8
Based on 1 Customer Validation
D-Sorbitol-d8 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.9%
- CAS. Nr.: 287962-59-8
- Formel: C6H6D8O6
- Molecular Weight:190.22
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 287962-59-8
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Unlabeled Cas 50-70-4
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Appearance Solid
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Molecular Weight 190.22
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Formel C6H6D8O6
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Color White to off-white
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SMILES
OC([2H])([2H])[C@](O)([2H])[C@](O)([2H])[C@@](O)([2H])[C@](O)([2H])C([2H])([2H])O
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Synonyms
Sorbitol-d8; D-Glucitol-d8
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (525.71 mM; Need ultrasonic)
DMSO : 100 mg/mL (525.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Ranjeet Prasad Dash, et al. Use of sorbitol as pharmaceutical excipient in the present day formulations - issues and challenges for drug absorption and bioavailability. Drug Dev Ind Pharm. 2019 Sep;45(9):1421-1429. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.2571 mL | 26.2854 mL | 52.5707 mL | 131.4268 mL |
| 5 mM | 1.0514 mL | 5.2571 mL | 10.5141 mL | 26.2854 mL | |
| 10 mM | 0.5257 mL | 2.6285 mL | 5.2571 mL | 13.1427 mL | |
| 15 mM | 0.3505 mL | 1.7524 mL | 3.5047 mL | 8.7618 mL | |
| 20 mM | 0.2629 mL | 1.3143 mL | 2.6285 mL | 6.5713 mL | |
| 25 mM | 0.2103 mL | 1.0514 mL | 2.1028 mL | 5.2571 mL | |
| 30 mM | 0.1752 mL | 0.8762 mL | 1.7524 mL | 4.3809 mL | |
| 40 mM | 0.1314 mL | 0.6571 mL | 1.3143 mL | 3.2857 mL | |
| 50 mM | 0.1051 mL | 0.5257 mL | 1.0514 mL | 2.6285 mL | |
| 60 mM | 0.0876 mL | 0.4381 mL | 0.8762 mL | 2.1904 mL | |
| 80 mM | 0.0657 mL | 0.3286 mL | 0.6571 mL | 1.6428 mL | |
| 100 mM | 0.0526 mL | 0.2629 mL | 0.5257 mL | 1.3143 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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