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Art. -Nr.: HY-127152

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Hippadine

(Synonyms: Pratorine)

Hippadine (Pratorine) is an alkaloid, which can be isolated from the plant Crinum macowanii. Hippadine exhibits heart-rate lowering and blood-pressure lowering effects in rats models with spontaneously hypertensive.

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CAS. Nr.: 52886-06-3
Formel: C₁₆H₉NO₃
Molecular Weight:263.25

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Hippadine Chemical Structure

CAS. Nr.: 52886-06-3

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Biologische Aktivität
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- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	96 μM Compound: 29	Growth inhibition of pro-apoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay Growth inhibition of pro-apoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay	[PMID: 22019045]
B16-F10	GI₅₀	34 μM Compound: 29	Growth inhibition of pro-apoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay Growth inhibition of pro-apoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay	[PMID: 22019045]
Hs 683	GI₅₀	19 μM Compound: 29	Growth inhibition of pro-apoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay Growth inhibition of pro-apoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay	[PMID: 22019045]
MCF7	GI₅₀	27 μM Compound: 29	Growth inhibition of human MCF7 cells after 72 hrs by MTT assay Growth inhibition of human MCF7 cells after 72 hrs by MTT assay	[PMID: 22019045]
PC-3	GI₅₀	>100 μM Compound: 29	Growth inhibition of human PC3 cells after 72 hrs by MTT assay Growth inhibition of human PC3 cells after 72 hrs by MTT assay	[PMID: 22019045]
SK-MEL-28	GI₅₀	>100 μM Compound: 29	Growth inhibition of pro-apoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay Growth inhibition of pro-apoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay	[PMID: 22019045]
T98G	GI₅₀	96 μM Compound: 29	Growth inhibition of pro-apoptotic stimuli-resistant human T98G cells after 72 hrs by MTT assay Growth inhibition of pro-apoptotic stimuli-resistant human T98G cells after 72 hrs by MTT assay	[PMID: 22019045]
U-373MG ATCC	GI₅₀	27 μM Compound: 29	Growth inhibition of pro-apoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay Growth inhibition of pro-apoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay	[PMID: 22019045]

Chemical Information

CAS. Nr. 52886-06-3
Molecular Weight 263.25
Formel C₁₆H₉NO₃
SMILES

O=C1N2C3=C(C=CC=C3C4=C1C=C5C(OCO5)=C4)C=C2
Synonyms

Pratorine
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mugabo P, et al., Effects of hippadine on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. J Ethnopharmacol. 2014 Dec 2;158 Pt A:123-31. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Hippadine

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

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Calculators

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Hippadine Related Classifications

HY-127152 Related Classifications