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Art. -Nr.: HY-179253

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KRAS-IN-47

KRAS-IN-47 is a KRAS inhibitor with IC₅₀ < 50 nM against KRAS G12V. KRAS-IN-47 can be used for the study of cancers.

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CAS. Nr.: 3079342-05-2
Formel: C₃₃H₂₇D₂F₅N₆O₂
Molecular Weight:638.63

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

KRAS-IN-47 Chemical Structure

CAS. Nr.: 3079342-05-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

KRAS-IN-47 is a KRAS inhibitor with IC₅₀ < 50 nM against KRAS G12V. KRAS-IN-47 can be used for the study of cancers^[1].

Alle Ras Isoform-spezifische Produkte anzeigen :

In Vitro

KRAS-IN-47 (Example 28) is a KRAS inhibitor with IC₅₀ < 50 nM against KRAS G12V^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC
Rat^[1]	10 mg/kg	p.o.	141 h·ng/g
Rat^[1]	2 mg/kg	i.v.	993 h·ng/g

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 3079342-05-2
Molecular Weight 638.63
Formel C₃₃H₂₇D₂F₅N₆O₂
SMILES

FC1=C(C2=CC(N)=CC3=C2C(C#C)=C(F)C(F)=C3)N=CC4=C1N=C(N=C4N5[C@@]6([H])[C@](COCC5)([H])[C@@H]6F)OC([2H])([2H])[C@@]78N(CCC8)C[C@@H](C7)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Michael David Bartberger, et al. Kras modulators. WO2025064542

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- Anwendung
Chemical Information
Reinheit & Dokumentation
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KRAS-IN-47

Alle Ras Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

KRAS-IN-47 Related Classifications

HY-179253 Related Classifications