Microcolin H
Based on 1 publication(s) in Google Scholar
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models.
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- Reinheit : 99.84%
- CAS. Nr.: 2408008-21-7
- Formel: C38H63N5O9
- Molecular Weight:733.93
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Speicherung:
Stored under nitrogen, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Microcolin H
More
Biologische Aktivität
Beschreibung
IC50 & Target
Phosphatidylinositol transfer protein, PITPα/β[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| NCI-H460 | IC50 |
47 nM
Compound: 4
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Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31468974] |
Chemical Information
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CAS. Nr. 2408008-21-7
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Appearance Solid
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Molecular Weight 733.93
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Formel C38H63N5O9
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Color White to off-white
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SMILES
O=C(N1[C@H](C=CC1=O)C)[C@H]2N(C[C@H](C2)O)C([C@H](C(C)C)N(C)C([C@H]([C@@H](C)OC(C)=O)NC([C@H](CC(C)C)N(C)C([C@H](C)CCCCCC)=O)=O)=O)=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Stored under nitrogen, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Acta Crystallogr D Struct Biol
2026 Mar 1. PMID: 41700428
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (68.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3625 mL | 6.8126 mL | 13.6253 mL | 34.0632 mL |
| 5 mM | 0.2725 mL | 1.3625 mL | 2.7251 mL | 6.8126 mL | |
| 10 mM | 0.1363 mL | 0.6813 mL | 1.3625 mL | 3.4063 mL | |
| 15 mM | 0.0908 mL | 0.4542 mL | 0.9084 mL | 2.2709 mL | |
| 20 mM | 0.0681 mL | 0.3406 mL | 0.6813 mL | 1.7032 mL | |
| 25 mM | 0.0545 mL | 0.2725 mL | 0.5450 mL | 1.3625 mL | |
| 30 mM | 0.0454 mL | 0.2271 mL | 0.4542 mL | 1.1354 mL | |
| 40 mM | 0.0341 mL | 0.1703 mL | 0.3406 mL | 0.8516 mL | |
| 50 mM | 0.0273 mL | 0.1363 mL | 0.2725 mL | 0.6813 mL | |
| 60 mM | 0.0227 mL | 0.1135 mL | 0.2271 mL | 0.5677 mL |
Microcolin H Related Classifications
HY-163001 Related Classifications
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