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Art. -Nr.: HY-105594

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Nivimedone

(Synonyms: BRL 10833 free base)

Nivimedone (BRL 10833 free base) is an orally active antiallergic agent. Nivimedone inhibits IgE-mediated passive cutaneous anaphylaxis in rats. Nivimedone suppresses antigen-induced histamine release from lung tissues passively sensitized with atopic serum. Nivimedone can be used in research related to bronchial asthma.

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CAS. Nr.: 49561-92-4
Formel: C₁₁H₉NO₄
Molecular Weight:219.19

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Please store the product under the recommended conditions in the Certificate of Analysis.

Nivimedone Chemical Structure

CAS. Nr.: 49561-92-4

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Biologische Aktivität
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- In Vivo
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Bioz

Biologische Aktivität

Beschreibung

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Nivimedone inhibits IgE-mediated, antigen-induced histamine release from passively sensitized human lung tissue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nivimedone inhibits IgE-mediated passive cutaneous anaphylaxis in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 49561-92-4
Molecular Weight 219.19
Formel C₁₁H₉NO₄
SMILES

O=C1C([N+]([O-])=O)C(C2=C1C=C(C)C(C)=C2)=O
Synonyms

BRL 10833 free base
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lumb EM, et al. The orally administered anti-allergic agent, sodium nivimedone (BRL 10833); efficacy in bronchial asthma and effects on IgE, complement and eosinophils. Br J Clin Pharmacol. 1979;8(1):65-74. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Nivimedone

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

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Nivimedone Related Classifications

HY-105594 Related Classifications