(+)-Niguldipine
(+)-Niguldipine is a potent dual inhibitor targeting L-type Ca2+ channels (Ki=85 pM) and α₁-adrenoceptor (Ki=52 pM). (+)-Niguldipine is promising for research of hypertension and cardiovascular diseases.
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- CAS. Nr.: 113165-32-5
- Formel: C36H39N3O6
- Molecular Weight:609.71
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Alle Calcium Channel Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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L-type calcium channel 85 pM (Ki) |
α1-adrenergic receptor 52 pM (Ki) |
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Cell Line
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Type | Value | Description | References |
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| Caco-2 | Inhibition |
92.98 %
Compound: NIGULDIPINE-(S)-(+)
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
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10.21203/rs.3.rs-23951/v1 |
Chemical Information
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CAS. Nr. 113165-32-5
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Molecular Weight 609.71
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Formel C36H39N3O6
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SMILES
O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(+)-Niguldipine Related Classifications
HY-137203 Related Classifications
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