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Art. -Nr.: HY-156465

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RIOK2-IN-2

RIOK2-IN-2 (8) is a RIOK2 inhibitor, with IC₅₀ values of 3.02 μM and 5.34 μM in MKN-1 and MOLT4 cells, respectively.

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CAS. Nr.: 2648987-17-9
Formel: C₂₇H₂₃F₃N₆O₂
Molecular Weight:520.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

RIOK2-IN-2 Chemical Structure

CAS. Nr.: 2648987-17-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

RIOK2-IN-2 (8) is a RIOK2 inhibitor, with IC₅₀ values of 3.02 μM and 5.34 μM in MKN-1 and MOLT4 cells, respectively^[1].

IC₅₀ & Target

RIOK2

Cellular Effect

Cell Line	Type	Value	Description	References
MKN-1	IC₅₀	1.05 μM Compound: 9	Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 37859717]
MOLT-4	IC₅₀	1.57 μM Compound: 9	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 37859717]
U-87MG ATCC	IC₅₀	1.25 μM Compound: 9	Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 37859717]

Chemical Information

CAS. Nr. 2648987-17-9
Molecular Weight 520.51
Formel C₂₇H₂₃F₃N₆O₂
SMILES

O=C1NC2=CC=C(C3=CC=C(OC)N=C3)C=C2C4=C1C=NN4C5=CC=C(N6CCNCC6)C(C(F)(F)F)=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huilan Xiong, et al. Exploration of tricyclic heterocycles as core structures for RIOK2 inhibitors. RSC Med Chem. 2023 Jul 21;14(10):2007-2011. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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