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Cat. No.: HY-B0135R

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Furosemide (Standard)

Name: Furosemide (Standard)
Brand: MedChemExpress
SKU: HY-B0135R
Price: 65.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Furosemide (Standard) is the analytical standard of Furosemide (HY-B0135). This product is intended for research and analytical applications. Furosemide is an orally active NKCC2 inhibitor that can cross the blood-brain barrier. Furosemide inhibits NKCC1, NKCC2, KCC2, KCC3, and KCC4. Furosemide selectively antagonizes GABA_A receptors containing α6 and β2/3 or β3γ2 subunits. Furosemide penetrates the blood-brain barrier and blocks renal tubular sodium-chloride reabsorption, increases urinary excretion of sodium, chloride, potassium, and calcium, and activates the renin-angiotensin-aldosterone system. Furosemide can be used in research on congestive heart failure, hypertension, and edema.

For research use only. We do not sell to patients.

Purity : 99.95%
CAS No.: 54-31-9
Formula: C₁₂H₁₁ClN₂O₅S
Molecular Weight:330.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Furosemide (Standard) Chemical Structure

CAS No.: 54-31-9

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 54-31-9
Appearance Solid
Molecular Weight 330.74
Formula C₁₂H₁₁ClN₂O₅S
Color White to off-white
SMILES

O=C(O)C1=CC(S(=O)(N)=O)=C(Cl)C=C1NCC2=CC=CO2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
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- Portuguese - PT (557 KB)
COA (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tucker BJ, et al. Effect of furosemide administration on glomerular and tubular dynamics in the rat. Kidney international. 1984 Aug;26(2):112-21.

[2]. Mitchell JR, et al. Hepatic necrosis caused by furosemide. Nature. 1974 Oct 11;251(5475):508-11.

[3]. Das PK, et al. Furosemide Stress Test and Renal Resistive Index for Prediction of Severity of Acute Kidney Injury in Sepsis. Cureus. 2023 Aug;15(8):e44408.

[4]. Kelly MR, et al. Pharmacokinetics of orally administered furosemide. Clin Pharmacol Ther. 1974 Feb;15(2):178-86.

[5]. Inoue M, et al. Mechanism of furosemide resistance in analbuminemic rats and hypoalbuminemic patients. Kidney international. 1987 Aug;32(2):198-203.

[6]. McCurley JM, et al. Furosemide and the progression of left ventricular dysfunction in experimental heart failure. Journal of the American College of Cardiology. 2004 Sep 15;44(6):1301-7.

[7]. Korpi ER, et al. Furosemide interactions with brain GABAA receptors. British journal of pharmacology. 1997 Mar;120(5):741-8.

[8]. Cataliotti A, et al. Brain natriuretic peptide enhances renal actions of furosemide and suppresses furosemide-induced aldosterone activation in experimental heart failure. Circulation. 2004 Apr 06;109(13):1680-5.

[9]. Duchin KL, et al. Effect of furosemide on renal autoregulation. Kidney Int. 1977 Dec;12(6):379-86. [Content Brief]

[10]. Orlov SN, et al. NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension. Genes & diseases. 2015 Jun;2(2):186-196.

[11]. Limmer F, et al. Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration. The FEBS journal. 2015 Oct;282(19):3786-98.

[12]. Suki WN, et al. Acute treatment of hypercalcemia with furosemide. N Engl J Med. 1970;283(16):836-840.

[13]. Osmanovic E, et al. The Effect of Furosemide on Arterial Blood Pressure, Blood Glucose Levels and Incidence of Heart Arrhythmias. American Journal of Internal Medicine. 2017;5(3):41-45.

[14]. Tenzing D, et al. Effect of furosemide in the treatment of high-altitude pulmonary edema. BMC Pulm Med. 2024 Mar 4;24(1):109.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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