FPR1 - formyl peptide receptor 1 Gene

Also Known as FPR; FMLP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2357

About FPR1

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,745,172-51,751,878 (from NCBI)

This gene has 4 transcripts (splice variants), 96 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in appendix (RPKM 94.6), bone marrow (RPKM 64.2) and 9 other tissues.

Summary

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by Microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

FPR1 Products (2)

mRNA Protein Name
NM_001193306.2 NP_001180235.1 fMet-Leu-Phe receptor
NM_002029.4 NP_002020.1 fMet-Leu-Phe receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
15210802 GOA
enables G protein-coupled receptor binding IDA
IDA: Inferred from direct assay
10823817 GOA
enables N-formyl peptide receptor activity IDA
IDA: Inferred from direct assay
12218158 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22447027 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
22859307 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FPR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (43 - 301)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

fMet-Leu-Phe receptor

  • N-formylpeptide chemoattractant receptor

FPR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FPR1 P21462 MAPK13 Homo sapiens O15264
Anti Tag CoIP
22447027
Intra
FPR1 P21462 GRK2 Homo sapiens P25098
Anti Tag CoIP
22447027
Cross: Cross-species interaction Intra: Intraspecies interaction

FPR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810874 FPR1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P810875 FPR1/ N-formyl peptide receptor 1 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Susceptibility To Localized Juvenile Periodontitis
Plague

  • Yersiniosis

  • Yersinia Infections

  • Infection By Yersinia Pestis

  • Pasteurella Pestis Infection

  • Pestilential Fever

  • Yersinia Pestis Infection
Pertussis

  • Whooping Cough

  • Bordetella Infections

  • Bordetella Infection

  • Bordetella Pertussis Infection

  • Wc - Whooping Cough

  • Whooping Cough Due To Unspecified Organism

  • Bordetellosis

  • Tussis Convulsiva

  • Whooping Cough, Unspecified Organism

  • Wc - [Whooping Cough]

  • Whooping Cough Due To B. Parapertussis

  • Infection Due To Bordetella Parapertussis
Aggressive Periodontitis

  • Juvenile Periodontitis

  • Periodontitis, Juvenile

  • Prepubertal Periodontitis
Periodontitis, Aggressive, 1

  • Pustulosis Palmaris Et Plantaris

  • Ppp

  • Periodontitis, Juvenile

  • Localized Pustular Psoriasis

  • Jpd

  • Periodontitis 1, Juvenile

  • Lpp

  • Palmoplantar Pustulosis

  • Prepubertal Periodontitis

  • Periodontitis, Aggressive 1

  • Periodontitis, Prepubertal

  • Periodontititis, Aggressive, 1

  • AP1

  • Juvenile Periodontitis

  • Periodontitis Juvenile

  • Pustulosis Of Palms And Soles

  • Generalized Pustular Psoriasis
Diamond-Blackfan Anemia 2

  • DBA2

  • Anemia, Diamond-Blackfan, 2

  • Anemia Diamond-Blackfan 2
Pulmonary Coin Lesion

  • Coin Lesion Of Lung

  • Solitary Pulmonary Nodule

  • Coin Lesion Lung
Hyper Ige Syndrome

  • Hyper-Ige Syndrome

  • Hyper Immunoglobulin E Syndrome

  • Hies

  • Hyper-Ige Recurrent Infection Syndrome

  • Hyperimmunoglobulin E Syndrome

  • Hyper Ige

  • Job Syndrome

  • Hartnup Disease
Anaerobic Meningitis
Bacterial Infectious Disease

  • Bacterial Infections

  • Bacterial Infection Nos

  • Disease Caused By Bacteria

  • Bacterial Disease Or Disorder
Rubeosis Iridis
High Grade Glioma

  • Malignant Glioma

  • Glial Cell Tumor

  • Glioma, Malignant

  • Malignant Neuroglial Tumor

  • Neuroglial Tumor

  • Glioma

  • Malignant Gliomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1122 Cyclosporin H 99.87% Unkown
HY-101283 HCH6-1 99.16% Unkown
HY-103286 PD176252 Antagonist 99.38% Unkown
HY-173591 T0080 99.94% Unkown
HY-19574 FPR Agonist 43 99.79% Unkown
HY-116216 PD 168368 Antagonist ≥99.0% Unkown
HY-P1795 Boc-dPhe-Leu-dPhe-Leu-Phe Antagonist 98.09% Unkown
HY-P2355 BOC-FlFlF Antagonist 98.31% Unkown
HY-156293 FPR1 antagonist 1 95.00% Unkown
HY-P1744 N-Formyl-Met-Leu-Phe-Lys 99.83% Unkown
HY-P10738 N-Formyl-MMYALF Inhibitor 99.78% Unkown
HY-P1121A WKYMVM-NH2 TFA 99.67% Unkown
HY-128113 AG-09/1 99.48% Unkown
HY-P1117 MMK1 99.71% Unkown
HY-117971 BVT173187 Inhibitor 99.97% Unkown
HY-N8152 Randialic acid B Inhibitor 99.94% Unkown
HY-144604 FPR2 agonist 2 Agonist 98.51% Unkown
HY-176403 FPR1 antagonist 3 Antagonist 98.07% Unkown
HY-P1118 Ac9-25 98.14% Unkown
HY-RS05085 FPR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10738A N-Formyl-MMYALF TFA Inhibitor / Unkown
HY-RS16619 Fpr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156294 FPR1 antagonist 2 / Unkown
HY-178919 N-19004 / Unkown
HY-N17383 Ligusticum cycloprolactam / Unkown
HY-P1117A MMK1 TFA / Unkown
HY-P1118A Ac9-25 TFA / Unkown
HY-P2355A BOC-FlFlF TFA Antagonist / Unkown
HY-RS23054 Fpr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991864 Annexuzlimab Inhibitor 98.67% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FPR1 VGNC VGNC:109505
Rattus norvegicus FPR1 RGD RGD:1310883
Mus musculus FPR1 MGD MGI:107443
Others FPR1 NCBI