Monascorubrin
Based on 1 Customer Validation
Monascorubrin is a compound that can be isolated from Monascus mycelia. Monascorubrin has activities such as anti-inflammatory, anti-tumor, antibacterial, and immunomodulatory. Monascorubrin also has certain embryotoxicity, with an ED50 of 4.3 μg for chicken embryos. Monascorubrin can be used for the research of tumors and inflammatory diseases.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 13283-90-4
- Formula: C23H26O5
- Molecular Weight:382.45
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
130.89 μM
Compound: 8
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Antiproliferative activity against human A431 cells after 72 hrs
Antiproliferative activity against human A431 cells after 72 hrs
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[PMID: 20655237] |
| IGROV-1 | IC50 |
102.88 μM
Compound: 8
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Antiproliferative activity against human IGROV1 cells after 72 hrs
Antiproliferative activity against human IGROV1 cells after 72 hrs
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[PMID: 20655237] |
| NCI-H460 | IC50 |
>50 μM
Compound: 8
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Antiproliferative activity against human NCI-H460 cells after 72 hrs
Antiproliferative activity against human NCI-H460 cells after 72 hrs
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[PMID: 20655237] |
Monascorubrin (0.2-1 mg/mL; 24 h) inhibits the growth of Candida pseudotropicalis and Bacillus subtilis[1].
Monascorubrin (10-5000 ng/well; 96-well plate; 6 h) shows weak inhibitory effect on the proliferation of Concanavalin A (HY-P2149)-stimulated mouse T-splenocytes, but significantly increases the intracellular calcium concentration in T-splenocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female ICR mice treated TPA (HY-18739) and DMBA (HY-W011845)[2]
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Dosage:2 μmol
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Administration:Topical application; twice a week; 18 weeks
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Result:Significantly suppressed TPA-induced tumor promotion, with the first tumor appearing at week 8 (vs. week 6 in control), 7% tumor-bearing mice at week 18 (vs. 100% in control), and an average of 0.1 tumors per mouse at week 18 (vs. 10.6 in control), representing a 99% reduction.
Chemical Information
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CAS No. 13283-90-4
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Appearance Solid
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Molecular Weight 382.45
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Formula C23H26O5
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Color Yellow to orange
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SMILES
O=C(O1)C(C(CCCCCCC)=O)=C2[C@]1(C)C(C3=COC(/C=C/C)=CC3=C2)=O
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Structure Classification
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Initial Source
Monascus purpureus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 25 mg/mL (65.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. L Martínková, et al. Biological activities of oligoketide pigments of Monascus purpureus. Food Addit Contam. 1999 Jan;16(1):15-24. [Content Brief]
[2]. Yasukawa K, et al. Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice. Oncology. 1994 Jan-Feb;51(1):108-12. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6147 mL | 13.0736 mL | 26.1472 mL | 65.3680 mL |
| 5 mM | 0.5229 mL | 2.6147 mL | 5.2294 mL | 13.0736 mL | |
| 10 mM | 0.2615 mL | 1.3074 mL | 2.6147 mL | 6.5368 mL | |
| 15 mM | 0.1743 mL | 0.8716 mL | 1.7431 mL | 4.3579 mL | |
| 20 mM | 0.1307 mL | 0.6537 mL | 1.3074 mL | 3.2684 mL | |
| 25 mM | 0.1046 mL | 0.5229 mL | 1.0459 mL | 2.6147 mL | |
| 30 mM | 0.0872 mL | 0.4358 mL | 0.8716 mL | 2.1789 mL | |
| 40 mM | 0.0654 mL | 0.3268 mL | 0.6537 mL | 1.6342 mL | |
| 50 mM | 0.0523 mL | 0.2615 mL | 0.5229 mL | 1.3074 mL | |
| 60 mM | 0.0436 mL | 0.2179 mL | 0.4358 mL | 1.0895 mL |
Monascorubrin Related Classifications
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