Polygodial
Based on 1 publication(s) in Google Scholar
Polygodial (Poligodial) is an antifungal potentiator. Polygodial is a sesquiterpene with anti-hyperalgesic properties.
For research use only. We do not sell to patients.
- Purity: 99.36%
- CAS No.: 6754-20-7
- Formula: C15H22O2
- Molecular Weight:234.33
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Polygodial
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
90 μM
Compound: 1
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Cytotoxicity against human A549 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 26360047] |
| A549 | IC50 |
2.5 μg/mL
Compound: 10
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Antitumor activity against human A549 cells
Antitumor activity against human A549 cells
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[PMID: 10579858] |
| A549 | IC50 |
2.5 μg/mL
Compound: 2
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Cytotoxicity against Homo sapiens (human) A549 cells
Cytotoxicity against Homo sapiens (human) A549 cells
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10.1016/0040-4020(95)00370-N |
| CHO | EC50 |
0.059 μM
Compound: 20
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Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels
Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels
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[PMID: 20356305] |
| Hs 683 | GI50 |
95 μM
Compound: 1
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Cytotoxicity against human Hs683 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human Hs683 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 26360047] |
| HT-29 | IC50 |
2.5 μg/mL
Compound: 10
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Antitumor activity against human HT-29 cells
Antitumor activity against human HT-29 cells
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[PMID: 10579858] |
| HT-29 | IC50 |
2.5 μg/mL
Compound: 2
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Cytotoxicity against Homo sapiens (human) HT-29 cells
Cytotoxicity against Homo sapiens (human) HT-29 cells
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10.1016/0040-4020(95)00370-N |
| MCF7 | GI50 |
75 μM
Compound: 1
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Cytotoxicity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 26360047] |
| MCF7 | IC50 |
12.4 μM
Compound: 13
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Antiproliferative activity against human MCF7 cells by SRB assay
Antiproliferative activity against human MCF7 cells by SRB assay
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[PMID: 28274626] |
| P388 | IC50 |
1.2 μg/mL
Compound: 10
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Antitumor activity against mouse P388 cells
Antitumor activity against mouse P388 cells
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[PMID: 10579858] |
| P388 | IC50 |
1.2 μg/mL
Compound: 2
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Cytotoxicity against Homo sapiens (human) P388 cells
Cytotoxicity against Homo sapiens (human) P388 cells
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10.1016/0040-4020(95)00370-N |
| SK-MEL-28 | GI50 |
65 μM
Compound: 1
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Cytotoxicity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 26360047] |
| SK-MEL-28 | IC50 |
2.5 μg/mL
Compound: 10
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Antitumor activity against human SK MEL28 cells
Antitumor activity against human SK MEL28 cells
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[PMID: 10579858] |
| SK-MEL-28 | IC50 |
2.5 μg/mL
Compound: 2
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Cytotoxicity against Homo sapiens (human) SK-MEL-28 cells
Cytotoxicity against Homo sapiens (human) SK-MEL-28 cells
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10.1016/0040-4020(95)00370-N |
| U-373MG ATCC | GI50 |
>100 μM
Compound: 1
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Cytotoxicity against human U373 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human U373 cells assessed as growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 26360047] |
Polygodial exhibits fungicidal activity against Saccharomyces cerevisiae, Candida albicans, and other fungal pathogens in standardized susceptibility tests (NCCLS). Polygodial (12.5 μg/mL, 3 hours) induces significant shrinkage compared to controls in Saccharomyces cerevisiae cells with the minimum fungicidal concentration (MFC) for 106 CFU/mL in RPMI 1640 medium[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S. cerevisiae cells
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Concentration:12.5 μg/mL
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Incubation Time:3 hours
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Result:Treated cells exhibited significant shrinkage compared to controls, and the organization of subcellular organelles appears either disrupted or compacted.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Non-fasted male Swiss mice (20-30 g) or male Wistar rats (150-180 g)[2]
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Dosage:0.1 to 10 mg/kg
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Administration:Injected i.p. 0.5 h before the injection of irritant substances
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Result:Produced significant inhibition of Acetic acid, Kaolin and Zymosan-induced writhing in mice.
Chemical Information
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CAS No. 6754-20-7
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Appearance Solid
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Molecular Weight 234.33
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Formula C15H22O2
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Color White to off-white
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SMILES
O=C[C@H]1C(C=O)=CC[C@@]2([H])C(C)(C)CCC[C@]12C
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Synonyms
Poligodial; Tadeonal
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Metabolism
IFT80 and TRPA1 cooperatively regulate bone formation by calcium signaling in response to mechanical stimuli. [Abstract]2025 May:166:156159. PMID: 39954781
Solvent & Solubility
DMSO : ≥ 100 mg/mL (426.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. I Kubo, et al. Polygodial, an antifungal potentiator. J Nat Prod. Jan-Feb 1988;51(1):22-9. [Content Brief]
[2]. G L Mendes, et al. Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). Life Sci. 1998;63(5):369-81. [Content Brief]
[3]. C S Lunde, et al. Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2000 Jul;44(7):1943-53. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2675 mL | 21.3374 mL | 42.6749 mL | 106.6871 mL |
| 5 mM | 0.8535 mL | 4.2675 mL | 8.5350 mL | 21.3374 mL | |
| 10 mM | 0.4267 mL | 2.1337 mL | 4.2675 mL | 10.6687 mL | |
| 15 mM | 0.2845 mL | 1.4225 mL | 2.8450 mL | 7.1125 mL | |
| 20 mM | 0.2134 mL | 1.0669 mL | 2.1337 mL | 5.3344 mL | |
| 25 mM | 0.1707 mL | 0.8535 mL | 1.7070 mL | 4.2675 mL | |
| 30 mM | 0.1422 mL | 0.7112 mL | 1.4225 mL | 3.5562 mL | |
| 40 mM | 0.1067 mL | 0.5334 mL | 1.0669 mL | 2.6672 mL | |
| 50 mM | 0.0853 mL | 0.4267 mL | 0.8535 mL | 2.1337 mL | |
| 60 mM | 0.0711 mL | 0.3556 mL | 0.7112 mL | 1.7781 mL | |
| 80 mM | 0.0533 mL | 0.2667 mL | 0.5334 mL | 1.3336 mL | |
| 100 mM | 0.0427 mL | 0.2134 mL | 0.4267 mL | 1.0669 mL |
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