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Cat. No.: HY-N1342

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Rocaglaol

Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells.

For research use only. We do not sell to patients.

CAS No.: 147059-46-9
Formula: C₂₆H₂₆O₆
Molecular Weight:434.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Rocaglaol Chemical Structure

CAS No.: 147059-46-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	6 nM Compound: rac-1	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-15	IC₅₀	6 nM Compound: rac-1	Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay	[PMID: 19655762]
HepG2	IC₅₀	70 nM Compound: rac-1	Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay	[PMID: 19655762]
HL-60	IC₅₀	3 nM Compound: rac-1	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 19655762]
HT-29	ED₅₀	0.0007 μM Compound: 9	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 23301897]
HT-29	ED₅₀	0.7 nM Compound: 9	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 23301897]
KB	IC₅₀	2 nM Compound: rac-1	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 19655762]
Lewis lung carcinoma cell line	IC₅₀	0.034 μg/mL Compound: 2	Cytotoxicity against mouse LL/2 cells Cytotoxicity against mouse LL/2 cells	[PMID: 10785416]
MCF7	IC₅₀	4 nM Compound: rac-1	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 19655762]
MCF7	IC₅₀	4 nM Compound: rac-1	Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay	[PMID: 19655762]
NIH3T3	IC₅₀	2 ng/mL Compound: 1	Growth inhibition of mouse NIH/3T3 cells Growth inhibition of mouse NIH/3T3 cells	[PMID: 8759160]
NIH3T3	IC₅₀	5.3 ng/mL Compound: 1	Growth inhibition of mouse NIH/3T3 cells expressing H-ras Growth inhibition of mouse NIH/3T3 cells expressing H-ras	[PMID: 8759160]
NIH3T3	IC₅₀	7 ng/mL Compound: 1	Growth inhibition of mouse NIH/3T3 cells expressing K-ras Growth inhibition of mouse NIH/3T3 cells expressing K-ras	[PMID: 8759160]
NIH3T3	IC₅₀	7.5 ng/mL Compound: 1	Growth inhibition of mouse NIH/3T3 cells expressing N-ras Growth inhibition of mouse NIH/3T3 cells expressing N-ras	[PMID: 8759160]
NRK	IC₅₀	10 ng/mL Compound: 1	Growth inhibition of rat NRK cells Growth inhibition of rat NRK cells	[PMID: 8759160]
NRK	IC₅₀	5.8 ng/mL Compound: 1	Growth inhibition of rat NRK cells expressing K-ras Growth inhibition of rat NRK cells expressing K-ras	[PMID: 8759160]
P388	IC₅₀	<0.01 μg/mL Compound: 2	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 10785416]
WEHI-164	IC₅₀	0.023 μg/mL Compound: 2	Cytotoxicity against mouse WEHI164 cells Cytotoxicity against mouse WEHI164 cells	[PMID: 10785416]

Chemical Information

CAS No. 147059-46-9
Molecular Weight 434.48
Formula C₂₆H₂₆O₆
SMILES

O[C@@H]1C[C@@H](C2=CC=CC=C2)[C@]3(C4=CC=C(OC)C=C4)OC5=CC(OC)=CC(OC)=C5[C@@]31O
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mi Q, et al. Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells. Anticancer Res. 2006;26(2A):947-952. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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