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Cat. No.: HY-146561

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S-HP210

Name: S-HP210
Brand: MedChemExpress
SKU: HY-146561
Price: 320.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

S-HP210 is a potent and selective glucocorticoid receptor (GR) with an IC₅₀ value of 1.92 μM for NF-κB transrepression (TR). S-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. S-HP210 is nontoxic at effective doses against mouse fibroblasts 3T3 cells.

For research use only. We do not sell to patients.

Purity : 98.12%
CAS No.: 3034696-13-1
Formula: C₂₂H₁₉N₃O₂S₂
Molecular Weight:421.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

S-HP210 Chemical Structure

CAS No.: 3034696-13-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 1.92 μM (NF-κB TR)^[1]

All NF-κB Isoforms :

Chemical Information

CAS No. 3034696-13-1
Appearance Solid
Molecular Weight 421.54
Formula C₂₂H₁₉N₃O₂S₂
Color White to off-white
SMILES

C[C@@H](C1=CC=CC=C1)NC(C2=CC=C(C=C2)CN3C(C4=C(NC3=S)C=CS4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (593.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3723 mL

11.8613 mL

23.7225 mL

5 mM

0.4745 mL

2.3723 mL

4.7445 mL

10 mM

0.2372 mL

1.1861 mL

2.3723 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu X, et al. Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation. Eur J Med Chem. 2022;237:114382. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3723 mL	11.8613 mL	23.7225 mL	59.3064 mL
	5 mM	0.4745 mL	2.3723 mL	4.7445 mL	11.8613 mL
	10 mM	0.2372 mL	1.1861 mL	2.3723 mL	5.9306 mL
	15 mM	0.1582 mL	0.7908 mL	1.5815 mL	3.9538 mL
	20 mM	0.1186 mL	0.5931 mL	1.1861 mL	2.9653 mL
	25 mM	0.0949 mL	0.4745 mL	0.9489 mL	2.3723 mL
	30 mM	0.0791 mL	0.3954 mL	0.7908 mL	1.9769 mL
	40 mM	0.0593 mL	0.2965 mL	0.5931 mL	1.4827 mL
	50 mM	0.0474 mL	0.2372 mL	0.4745 mL	1.1861 mL
	60 mM	0.0395 mL	0.1977 mL	0.3954 mL	0.9884 mL
	80 mM	0.0297 mL	0.1483 mL	0.2965 mL	0.7413 mL
	100 mM	0.0237 mL	0.1186 mL	0.2372 mL	0.5931 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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MCE Japan Authorized Agent:

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S-HP210

All NF-κB Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Solvent & Solubility

In Vitro:

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

S-HP210 Related Classifications

HY-146561 Related Classifications

Bioz

Keywords

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